Platinum-functionalized high-performance ceramics in PoC container

Simple SummaryContent extracted from patent full text and abstract with AI.

In a new container concept, patient cells are pre-incubated on the implant surface. In combination with platinum functionalization, but also on all common implants, the ingrowth behavior can be significantly improved by this point-of-care (PoC) strategy. An excerpt from our experimental data: The PoC container, consisting of a container concept and platinum-functionalized high-performance ceramics from MKM Engineering GmbH, represents a further step in implantology toward the targeted improvement of ingrowth behavior through surface modification. Traces of the precious metal platinum in the high-performance ceramics make the implant surface more hydrophilic overall. In addition, cell adhesion is enhanced via universal protein binding. Even targeted cell adhesion motifs can be applied to the implant surface in a single process step, either by the manufacturer or the user, without the need for further chemical coupling steps. Our patent application describes the platinum functionalization of ceramic materials and an incubator concept. In a glass container, dimensioned for an implant threaded pin, which can be filled with sterile growth medium, patient cells from a punch biopsy are introduced via a cannula. Through a self-closing septum, this patient punch sample (or a saliva sample containing cells from the oral mucosa) is introduced directly by needle injection, thereby individualizing the implant surface. Pre-incubation with patient material is known to improve ingrowth behavior.

Use CasesContent extracted from patent full text and abstract with AI.

• Pre-coating or functionalizing dental implants with the patient's own cells, proteins, or extracellular matrix components before implantation.
• In vitro preparation of personalized dental implants for improved patient outcomes.

BenefitsContent extracted from patent full text and abstract with AI.

• Individualized and improved osseointegration of ceramic implant materials and healing.

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Inventors & Applicants

Patent Abstract

The present invention refers to a temperature resistant dental implant container with dental implant comprising a polygonal or cylindrical, optically transparent container with a conically tapered interior for receiving a dental implant, a needle-pierceable, flexible, and liquid-tight septum, a lid which is separably connected to the container, wherein the interior of the container is configured to fix the position of the dental implant between the bottom of the septum and the bottom of the interior, and a dental implant comprising a conditioned surface. Further its use for transport and storage, and a method for in vitro cellular coating a dental implant are described.