enGenes
enGenes Biotech is an Austrian biotechnology company specializing in cost-effective, high-yield production of recombinant proteins, plasmid DNA, peptides, and bioprocessing solutions using advanced microbial technologies.
About
enGenes Biotech GmbH is an innovative biotechnology company based in Vienna, Austria, founded in 2014 as a spin-off from BOKU University. The company specializes in the research, development, and manufacturing of high-yield recombinant proteins, peptides, and plasmid DNA, with a focus on scalable and cost-effective solutions for pharmaceutical, diagnostic, and industrial applications. enGenes has pioneered platforms including enGenes-eXpress—a patented, growth-decoupled E. coli expression system—and related technologies enabling record protein titers, extracellular protein secretion, continuous biomanufacturing, and marker-free plasmid production. Their modular service offerings cover cloning/vector optimization, host cell engineering, high-throughput screening, process development, scale-up, and tech transfer. Driven by a commitment to sustainability, innovation, and scientific excellence, enGenes collaborates with international partners to accelerate biopharmaceutical innovation and provide tailored solutions from proof-of-concept to commercial scale.
Products & Services
- Recombinant protein production (custom and modular services)
- Plasmid DNA production (including research-grade, lab-scale, scale-up, marker-free and minicircle production)
- Bioconjugate production
- enGenes-eXpress™ platform for growth-decoupled microbial expression
- enGenes-eXtra™ technology for extracellular/secretion-based protein production
- enGenes-eXpand™ platform for site-specific non-canonical amino acid incorporation
- enGenes-eXcite™ technology for continuous biomanufacturing
- enGenes-eXcess™ plasmid DNA production platform
- enGenes-eXchange™ antibiotic-free manufacturing technology
- eXrase™ endonuclease for enhanced protein purification and viscosity reduction
- eXfinity affinity ligands (Protein A and custom ligands)
- Tech transfer and process optimization services
- Feasibility studies and technology development projects
Use Cases & Case Studies
- Case studies in the production of recombinant proteins for pharmaceutical, diagnostic, and industrial purposes.
- Research publications showing increased protein yield and quality using enGenes-eXpress strains.
- Implementation of continuous and scalable production processes for biopharma manufacturing.
- Antibiotic-marker-free and continuous production use cases for gene therapy and vaccine development.
Partnerships & Collaborations
- ECOnti project (consortium with Novasign GmbH, Qubicon AG, SimVantage GmbH, Tosoh, and BOKU University)
- iCAP Project (with Novasign® and Qubicon® AG)
- Collaboration with TU Wien (Technical University Vienna)
- Collaboration with ACIB GmbH
- Participation in EU-funded SynBIOcarb program
Awards & Recognition
- Significant funding from Austrian Research Promotion Agency (FFG) for multiple projects