Novasign GmbH
Novasign GmbH accelerates bioprocess development with advanced hybrid modeling software and tailored consulting services.
About
Novasign GmbH is an Austrian technology company specializing in accelerating the development and optimization of bioprocesses through advanced hybrid modeling, smart experimental design, and digital twin technologies. By integrating machine learning, engineering know-how, and data-driven strategies into intuitive software tools, Novasign helps biopharmaceutical, enzyme, and cultured food industries to streamline their development workflows, reduce experimental effort, and enhance process understanding and control. The company's core mission is to pioneer digital transformation in bioprocessing, enabling faster, more robust market launches for pharmaceuticals, biosimilars, and novel food products. Novasign emphasizes open integration, transparency, and client co-creation, providing consulting, software, and training to enable Bioprocessing 4.0.
Products & Services
- Novasign Studio – Cloud-based collaborative bioprocess modeling platform
- Hybrid Modeling Toolbox – Desktop software for process modeling, simulation, and optimization
- Digital Twin platform – Virtual simulation of bioprocesses for process optimization and control
- Process development consulting for design, optimization, and scale-up
- Software training (standard and customer-specific)
- Bioprocess modeling consulting (cultivation, harvest, filtration, and novel bioprocesses)
- Custom experimental workflows and data evaluation
- Integration with third-party solutions (e.g., Qubicon®)
- Economic process predictor tools and workflows
Use Cases & Case Studies
- Significant reduction in experiments (up to 70%) for bioprocess characterization using hybrid modeling and intensified DoE
- Viral vector manufacturing with 64% fewer experiments, leading to cost and time savings
- Hybrid model-driven soft sensing for real-time process monitoring at Siemens LivingLab
- Model transferability and reduced experimental burden in CHO process development across scales (from shake flask to 15L bioreactor)
- Advanced online sensor modeling and process analytics for HEK 293 gene therapy in collaboration with Takeda
- Optimization of monoclonal antibody (mAb) filtration processes for higher yield and lower resource use
- Digitization of microbial fermentation for education and hands-on training at FH Campus Wien
Partnerships & Collaborations
- ACIB – Austrian Centre of Industrial Biotechnology
- Antleron – Collaboration on advanced therapy medicinal products modeling
- bespark*bio – Process development organization, partnered on vaccine and cell/gene therapy processes
- BOKU University (spin-off origin)
- FH-campus Wien – University partnership for training and process digitization
- Qubicon – Software integration for hybrid models and process control
- SimVantage – Integration of CFD into hybrid modeling workflow
- Takeda – Industrial collaboration on gene therapy process monitoring and modeling
Awards & Recognition
- Staatspreis Consulting 2024
- ECONOVIUS 2024
- Constantinus Award 2024 (1st Place) for Accelerating Bioprocess Development Using Artificial Intelligence
- EY Scale-up Award 2024 (Biotech and Health Finalist)
- Mercur 2024 Award (WKO Innovationspreis)
- PHÖNIX Award 2021
- BOKU Technet Innovation Award 2019
- Best talk @10th ÖGMBT Annual Meeting 2018