Method for Producing a Coumarin-caged Forskolin Derivative, Forskolin Derivative and Use of the Forskolin Derivative

Simple SummaryContent extracted from patent full text and abstract with AI.

The invention describes a chemical process for synthesizing 'coumarin-caged' forskolin derivatives. These derivatives are biologically inactive versions of forskolin that can be activated by exposure to UV light, which releases active forskolin inside living cells or tissues. The patent also claims the new compounds produced by this synthesis and their applications in precisely controlling cellular signaling by temporally and spatially releasing forskolin using light.

Use CasesContent extracted from patent full text and abstract with AI.

• Cell signaling research to study cAMP and calcium pathways with high time and spatial resolution
• Pharmacological experiments needing precise temporal delivery of forskolin to specific locations in cells or tissues
• Optopharmacology, enabling control of biological processes in live-cell imaging or tissue studies
• Functional studies of GPCR (G-protein coupled receptor) mediated pathways and adenylyl cyclase activation
• High-throughput screening for drug discovery involving cAMP or calcium signaling modulation
• Studies where direct addition of forskolin is not suitable due to diffusion or timing limitations

BenefitsContent extracted from patent full text and abstract with AI.

• Enables very precise, light-triggered activation of forskolin in live cells/tissue, improving experimental control
• Reduces unwanted side effects by limiting active forskolin release to desired times and locations
• Facilitates high-resolution studies of rapid biochemical signaling events (sub-second kinetics)
• Provides a water-soluble, photolyzable forskolin derivative not previously available
• Compatible with standard fluorescence-based detection methods for real-time monitoring
• Useful in both academic research and drug development pipelines for signaling pathway studies

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to a process for preparing a coumarin-caged forskolin derivative, to the forskolin derivative as such and to the use of the forskolin derivative.