Biosensor for Electrochemical Detection of Malaria Biomarkers

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention describes a flexible, multielectrode array biosensor platform for the electrochemical detection of disease biomarkers, especially for malaria and respiratory viruses (like SARS-CoV-2). The sensor uses immobilized aptamers on the electrode sets to specifically and simultaneously detect multiple biomarkers from a single biological sample, allowing differentiation of pathogens and variants. Its flexible substrate and design enable cost-effective production, robust handling, multiplexing, and integration with digital output devices for easy analysis and epidemiological monitoring.

Use CasesContent extracted from patent full text and abstract with AI.

• Rapid point-of-care diagnosis of malaria, including distinction between Plasmodium species (e.g., P. falciparum, P. vivax) from blood samples.
• Early and specific detection of respiratory viral biomarkers (e.g., SARS-CoV-2, influenza, RSV) from nasal/throat swabs.
• Simultaneous detection and quantification of multiple pathogens or variants in a single test to help differential diagnosis in patients with similar symptoms.
• Integration into portable devices for home, clinic, or remote health settings to support decentralized diagnostics.
• Digital epidemiological surveillance by real-time connected data transfer from test results.
• Platform for research and development of diagnostic tests for emerging infectious diseases and pandemic preparedness.

BenefitsContent extracted from patent full text and abstract with AI.

• Highly sensitive and specific detection due to aptamer-based recognition, superior to conventional antibody-based rapid tests, especially under challenging environments (e.g., high temperature, humidity).
• Multiplex capability – can distinguish multiple pathogens and variants in a single, small-volume sample.
• Cost-effective and scalable manufacturing thanks to the use of flexible substrates and simplified electrode/passivation processes.
• Robust against temperature and chemical influences; less prone to degradation than antibody sensors, leading to longer shelf-life and lower transport/storage constraints.
• Quantitative and digital output allows for automated, user-friendly readout, minimizing interpretation errors and supporting automated epidemiology.
• Small device and sample requirements enable minimally invasive or even remote/self-testing.
• Easy adaptability to new diseases by changing the targeting aptamers, making it a universal diagnostic platform.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to multielectrode-array biomarker sensors, to kits containing same, to methods of manufacture and to corresponding uses and applications.