Electrochemical Cell and Method for Separation of Carrier-Free F from a Solution at an Electrode

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The invention describes an electrochemical cell and a method for efficiently extracting carrier-free radionuclide fluoride ions (specifically 18F-) from an aqueous solution. The process involves using diamond-coated electrodes—preferably with boron-doped diamond layers—which improve both the fixation and subsequent release of 18F-. With this setup, the 18F- is first collected on the anode, the cell is dried, and then the ion can be rapidly and efficiently eluted into an organic solution using a transfer catalyst, all while minimizing losses common in traditional methods.

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• Production of 18F-labeled compounds for positron emission tomography (PET) tracers in medical imaging.
• Radiopharmaceutical manufacturing facilities where high-yield extraction of radionuclides is critical.
• Laboratory-scale radioisotope purification and concentration for research purposes.
• Automated synthesis modules for routine PET tracer production.
• Nuclear medicine departments requiring consistent, predictable yields of 18F for clinical diagnostics.

BenefitsContent extracted from patent full text and abstract with AI.

• Significantly reduces loss of valuable 18F-, yielding more than 90% recovery compared to traditional methods (~60%).
• Faster and more efficient extraction process, important for short-lived radioisotopes like 18F.
• Diamond-coated electrodes are chemically inert and robust, preventing contamination and electrode degradation.
• Modular cell design allows for batch or flow operation, increasing flexibility for different production scales.
• Enhanced specificity and cleanliness in the extraction process, reducing byproducts and impurities.
• Fine control over radionuclide elution, allowing for portioned dosing or multiple applications from a single production run.

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Patent Abstract

The invention relates to an electrochemical cell and to a method for separating carrier-free radionuclides from a solution on an electrode. According to the invention, 18F- in an electrochemical cell is precipitated from an aqueous solution on an anode (1), which is diamond-coated. Subsequently, the electrochemical cell is dried and supplied with a fluid containing a transfer catalyst, the anode is preferably switched as cathode and the 18F- is converted to the liquid phase.