Process for the Fermentative Production of Cadaverine

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes genetically engineered microorganisms, particularly strains of Corynebacterium and Escherichia coli, that are modified to overproduce cadaverine (1,5-diaminopentane) via fermentation. The innovation involves boosting the expression of specific genes, mainly those encoding lysine decarboxylase and a lysine/cadaverine antiporter, enabling efficient cadaverine biosynthesis directly from renewable raw materials such as glucose or sucrose, making the process more sustainable and potentially cost-effective compared to conventional petrochemical methods.

Use CasesContent extracted from patent full text and abstract with AI.

• Production of bio-based polyamides (nylons) and specialty plastics for automotive, sports, textiles, and consumer goods industries.
• Manufacture of renewable, sustainable alternatives to petrochemical-derived diamines in polymer supply chains.
• Use in the synthesis of adhesives, coatings, and resins that require diamines as key monomers.
• Potential application in the agrochemical industry for creating plant growth regulators or protective agents derived from cadaverine-related chemistries.
• Fermentation-based production of cadaverine for use as an intermediate in pharmaceuticals and fine chemicals.

BenefitsContent extracted from patent full text and abstract with AI.

• Reduces reliance on petrochemical feedstocks by utilizing renewable raw materials, such as plant-derived sugars, as carbon sources.
• Provides a more environmentally friendly and sustainable cadaverine production route through fermentation, reducing carbon emissions and resource consumption.
• Improves process economics by enabling direct microbial production of cadaverine without the need for external lysine feeding or complex biocatalytic steps.
• Allows for scalable and flexible manufacturing using standard fermentation technologies widely used in biotechnology and industrial microbiology.
• Facilitates higher cadaverine yields through genetic modifications, potentially lowering production costs and increasing competitiveness with chemical synthesis.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to recombinant microorganisms in which polynucleotides coding for lysine decarboxylase are amplified, and using which cadaverine (1,5-diaminopentane) is produced by fermentation, wherein, as C source, preferably use is made of renewable raw materials such as, for example, glucose, sucrose, molasses etc.