Nucleotide sequences of coryneform bacteria coded for proteins participating in L-serine metabolism and method for microbial production of L-serine

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention describes genetically engineered coryneform bacteria, specifically of the genus Corynebacterium, with a modified or deactivated L-serine dehydratase gene. By reducing or eliminating this enzyme's activity, the modified bacteria accumulate much higher levels of L-serine during fermentation. The patent also provides the relevant nucleotide sequences and methods for producing L-serine using these genetically optimized microorganisms.

Use CasesContent extracted from patent full text and abstract with AI.

• Industrial-scale biosynthesis of L-serine for use as a feedstock in the food and animal feed industries.
• Production of L-serine as a precursor for pharmaceutical products, such as in the synthesis of amino-acid-derived drugs.
• Use in biomanufacturing processes where high-yield and cost-effective production of L-serine is required.
• Creation of building blocks (such as tryptophan) for further industrial chemical syntheses.

BenefitsContent extracted from patent full text and abstract with AI.

• Enables significantly increased yield of L-serine in microbial fermentation, improving cost-effectiveness of production.
• Reduces production reliance on costly or complex precursors by enabling direct synthesis from carbohydrates.
• Offers flexibility to tailor-make L-serine overproducing strains for specific industrial applications.
• Makes possible more efficient, stable, and scalable L-serine production processes using non-pathogenic, well-characterized bacteria.
• Facilitates downstream biotechnological and pharmaceutical development by providing reliable L-serine sources.

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Inventors & Applicants

Patent Abstract

This invention relates to the nucleotide sequence of coryneform bacteria coding for proteins which are involved in L-serine metabolism with reduced and switched off L-serine dehydratase activity. The invention also relates to microorganisms used in methods for producing L-serine.