Device for a Sterile Liquid Transfer

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This invention relates to a device and system for the sterile transfer of liquids, particularly in biotechnological processes involving bioreactors. The device is designed to be compatible with both manual and automated (robotized) equipment, enabling the sterile addition or removal of liquid samples without needing a cleanroom or special sterile environment. It uses a unique two-part structure with integrated barriers and connectors, ensuring easy integration with standard laboratory devices and liquid-handling robots.

Use CasesContent extracted from patent full text and abstract with AI.

• Automated, sterile sampling and dosing in laboratory bioreactors for research or production.
• Integration with pipetting robots or automated liquid-handling systems for bioprocess monitoring and control.
• Retrofitting existing laboratory setups or bioreactors to enable sterile, automated liquid transfer without complex cleanroom requirements.
• Transfer of samples to and from analytical instruments (e.g., HPLC, mass spectrometers, flow cytometers) in a sterile manner.
• Flexible set-ups for testing or developing new bioprocesses where frequent, sterile sampling is needed.

BenefitsContent extracted from patent full text and abstract with AI.

• Allows sterile, bidirectional liquid transfer (addition and sampling) without a full cleanroom or laminar flow environment.
• Compatible with both manual and automated (robotic) systems, increasing flexibility and ease of use.
• Easy integration and retrofitting for existing bioreactor and laboratory equipment.
• Minimizes risk of contamination and cross-contamination during liquid transfer.
• Reduces labor and need for operator presence, enabling unattended or remote operation (e.g., overnight processes).
• Reduces unnecessary waste and sampling volumes, preserving valuable samples and minimizing process disturbance.
• Device and system are mobile, transportable, and adaptable to a wide range of laboratory configurations.
• Supports both single-use and reusable implementations, aiding in cost control and sustainability.

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Inventors & Applicants

Patent Abstract

The invention relates to a device for a sterile liquid transfer and to a system containing multiple devices according to the invention. The invention also relates to a device and a system for coupling one or more bioreactors to automated or robotizable liquid transfer equipment. The invention also relates to a method for producing the device according to the invention and to the use thereof.