Molecule Mixture Comprising an Amphipathic Molecule Type A, Which Has a Positive Total Charge in the Hydrophilic Range, and an Amphipathic Molecule Type B and a Polyphenol C, Method for Producing Said Molecule Mixture and Use Thereof

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes a novel molecular mixture composed of two amphipathic molecules—Type A (with a positively charged hydrophilic region) and Type B (neutral in the hydrophilic region)—and a polyphenol (such as resveratrol, curcumin, hydroxyflavon, or genistein). These components can be formulated into liposomes for improved delivery of polyphenols to living cells. The core innovation is that the polyphenol becomes an integral part of the liposomal membrane, enabling efficient, targeted, and controlled delivery into target cells, while simultaneously protecting the polyphenol from oxidation.

Use CasesContent extracted from patent full text and abstract with AI.

• Therapeutic delivery of polyphenols (like resveratrol or curcumin) for the treatment of diseases caused by oxidative stress, such as inflammatory diseases or neurodegenerative disorders.
• Targeted chemotherapy in oncology, using high concentrations of polyphenol-loaded liposomes to selectively induce toxicity in cancer cells.
• Development of pharmaceutical products (medications, tablets, or infusible solutions) with enhanced bioavailability and stability of plant-derived polyphenols.
• Nutraceutical or cosmeceutical formulations where controlled release and cellular uptake of antioxidant polyphenols is desired.
• Cell biology or laboratory research involving the study of cell membrane fusion, drug delivery, or protective effects of polyphenols in cell culture systems.

BenefitsContent extracted from patent full text and abstract with AI.

• Provides significantly improved cellular uptake and controlled release of polyphenols compared to traditional delivery systems or neutral liposomes.
• Protects sensitive polyphenolic compounds from premature oxidation, prolonging their shelf-life and in vivo effectiveness.
• Allows for precise and tunable formulation of the delivery system with flexible molar ratios for different therapeutic requirements.
• Reduces the required therapeutic dosage by increasing effective bioavailability, resulting in potentially fewer side effects.
• Supports the formulation of both aqueous and solid dosage medicinal products with stabilized antioxidant content.
• Enables efficient drug targeting and fusion with cell membranes, maximizing pharmacological impact and minimizing off-target effects.

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Inventors & Applicants

Patent Abstract

The invention relates to a molecule mixture comprising an amphipathic molecule type A, which has a positive total charge in the hydrophilic range, and an amphipathic molecule type B and a polyphenol C, to a method for the production of said molecule mixture and to the use thereof, the molecule types A and B being present in a molecular ratio of A:B of 1(±0.2):1(±0.2) mol/mol. The invention also relates to a method for the production of said mixture and to the use thereof.