New peptide containing amino acid sequences and their homologues and polymers and their homologues, useful to inhibit fibril formation of amyloid-beta peptides and to bind aggregated amyloid beta peptides to treat Alzheimers disease

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This patent describes novel peptides and related polymers that include specific amino acid sequences (identified as SEQ ID NO: 1, 2, and 3) and their homologues. These peptides can inhibit the formation of amyloid-beta fibrils and bind to aggregated amyloid-beta, which are key pathological features of Alzheimer's disease. The invention also covers methods for preparing these peptides and kits containing them.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of Alzheimer's disease by reducing amyloid-beta plaque formation
• Development of vaccines or therapeutic agents targeting amyloid-beta aggregation
• Diagnostic kits for detecting amyloid-beta aggregates in research or clinical settings
• Potential use as neuroprotective agents in neurodegenerative disease research

BenefitsContent extracted from patent full text and abstract with AI.

• May help slow or prevent the progression of Alzheimer's disease by inhibiting harmful amyloid-beta fibril formation
• Can bind to aggregated amyloid-beta, possibly aiding in their clearance from the brain
• Offers a targeted approach, which could reduce side effects compared to less specific therapies
• Supports development of peptide-based vaccines or therapeutic interventions for neurodegenerative conditions

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Patent Abstract

Peptide containing at least one amino acid sequence consisting of SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3 and its homologues, fragments and parts and polymers having SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3 and their homologues, is new, where the sequences are not defined. Independent claims are included for: (1) preparing the peptide; and (2) a kit comprising the peptide. ACTIVITY : Neuroprotective; Nootropic; Anabolic. MECHANISM OF ACTION : Vaccine.