Device and Method for Effective Non-Invasive Neurostimulation by Means of Varying Stimulation Sequences

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This invention describes a device and method for non-invasive neuromodulation that aims to treat neurological and psychiatric disorders caused by abnormal synchronous neuronal activity, such as Parkinson’s disease, tinnitus, epilepsy, and others. The device delivers stimuli to the brain or spinal cord through multiple stimulation channels, using specific sequences that remain constant for a set number of repetitions before changing. This approach is shown to desynchronize abnormally synchronized neuron populations more effectively and robustly than rapidly varying or standard sequences, leading to lasting therapeutic effects.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of movement disorders like Parkinson’s disease and dystonia
• Therapy for chronic conditions such as tinnitus, migraine, and pain syndromes
• Managing psychiatric conditions including depression, schizophrenia, OCD, and borderline personality disorder
• Rehabilitation following stroke or traumatic neurological injury
• Intervention for epilepsy to reduce abnormal brain synchrony
• Alleviation of symptoms in conditions like essential tremor, Tourette syndrome, ADHD, and sleep disorders
• Home or clinical use for adaptive neurostimulation using wearable or portable devices

BenefitsContent extracted from patent full text and abstract with AI.

• Non-invasive therapy, reducing risks and complications compared to surgical or implant-based treatments
• Applicable to a broad range of neurological and psychiatric disorders associated with abnormal neural synchrony
• Improved and longer-lasting desynchronization effects compared to previous approaches
• Resilient to variations in stimulation intensity and patient’s physiological state, enabling more reliable treatment
• Allows for personalization and adaptation of stimulation protocols based on patient response
• Supports both open-loop and closed-loop (adaptive, sensor-guided) operation
• Simplifies patient experience by using sensory modalities such as sound, touch, or light
• Potential for home-based or ambulatory treatment, increasing accessibility and convenience

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Inventors & Applicants

Patent Abstract

The invention relates to a device for stimulating neurons, comprising - a non-invasive stimulation unit for generating stimuli in a plurality of stimulation channels, the stimulation unit being designed such that the stimuli stimulate a neuron population in the brain and/or spinal cord of a patient via the stimulation channels in different locations, and - a control unit, which controls the stimulation unit such that the stimulation unit repeatedly generates sequences of stimuli, - the order of the stimulation channels in which stimuli are generated within a sequence being constant for at least 20 successively generated sequences and being then varied.