Translocation of Synthetic Polymers by Lipid Membranes

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes novel copolymers, specifically with alternating hydrophobic and hydrophilic units, designed to facilitate the transport of active ingredients (such as drugs or biologically active molecules) across lipid bilayer membranes, like those found in cells. By tuning the chemical structure, these polymers can selectively deliver substances into and through biological membranes without the toxicity or adverse interactions of conventional carriers. They are soluble under physiological conditions and can form associations with drugs, either covalently or non-covalently, enabling targeted and controlled release.

Use CasesContent extracted from patent full text and abstract with AI.

• Delivering pharmaceutical agents directly into cells across the cell membrane for more effective therapies, including cancer treatment.
• Transporting biologically active substances (such as peptides, proteins, genetic material, or markers) into cells for research, diagnostics, or therapeutic purposes.
• Facilitating targeted drug delivery to specific tissues or organs, thereby increasing the local concentration of drugs at the disease site.
• Development of novel formulations for controlled drug release based on temperature responsiveness (LCST properties).
• Ex-vivo delivery or screening of various drug molecules across artificial membranes to optimize drug formulations.
• Incorporation in drug delivery kits or systems for personalized medicine.

BenefitsContent extracted from patent full text and abstract with AI.

• Efficient transport of both hydrophilic and hydrophobic drugs or biologically active agents across biological barriers such as cell membranes.
• Reduces premature drug elimination and improves bioavailability by protecting drugs until they reach the target site.
• Minimizes unwanted interactions or toxicity associated with traditional ionic delivery carriers, due to the non-ionic and biocompatible nature of the polymers.
• Polymers' solubility and behavior can be customized according to needs, enabling temperature-controlled drug release (via LCST tuning).
• Versatility in bonding to active ingredients, offering both covalent and non-covalent attachment, allowing for customizable release profiles.
• Potential for enhanced specificity in drug targeting, thus reducing side effects and increasing therapeutic efficiency.

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Inventors & Applicants

Patent Abstract

The present invention relates to a copolymer containing alternating hydrophobic and hydrophilic units and to the use of said copolymers as carriers for active ingredients by a double lipid layer, in particular a lipid membrane.