Sequences of an Ih ion channel and use thereof

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent discloses newly identified and isolated nucleic acid sequences encoding Ih ion channels (hyperpolarization-activated cation channels) from various sources, including human, rat, cattle, sea urchin, and Drosophila. It describes how these DNA or RNA sequences can be used to produce functional Ih channel proteins in host cells for research, screening, diagnostics, or therapeutic purposes. The invention includes methods for using these sequences and proteins to detect or treat disorders related to ion channel dysfunction, particularly in cardiovascular and neurological systems.

Use CasesContent extracted from patent full text and abstract with AI.

• Development of screening assays for drugs that modulate Ih ion channel activity.
• Diagnostic kits for identifying mutations or dysfunctions in Ih channels associated with heart or neurological diseases.
• Research tools for understanding the physiological role and pathology of Ih channels in human and animal tissues.
• Gene therapy approaches to treat conditions caused by defective Ih ion channels, such as cardiac arrhythmias or certain neuropsychiatric or sleep disorders.
• Pharmaceutical compositions containing Ih channel DNA, RNA, or proteins for therapeutic use in cardiovascular or consciousness disorders.
• Antibody production for detection or study of Ih channel proteins.

BenefitsContent extracted from patent full text and abstract with AI.

• Provides the first description and isolation of DNA/RNA sequences encoding Ih ion channels, enabling detailed molecular studies.
• Enables the production of pure and functional ion channels for high-throughput drug screening and pharmacological characterization.
• Facilitates the development of highly specific diagnostic tests for cardiovascular and neurological conditions involving Ih channel dysfunction.
• Supports gene therapy strategies by providing full-length, functional ion channel genes for replacement or repair.
• Allows earlier and more precise detection of genetic mutations affecting these ion channels, improving patient stratification and tailored treatments.
• New antibody reagents enable detailed protein-level detection and research into channel localization and function.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to an isolated or purified human nucleic acid, preferably a DNA, comprising a nucleotide sequence encoding an Ih ion channel. The invention further relates to a vector comprising the isolated or purified nucleic acid, a host cell comprising the vector, and a composition comprising the isolated or purified nucleic acid and a carrier therefore. The invention also provides a polypeptide or protein encoded by the nucleic acid, and a method of treating a mammal for a cardiovascular disorder.