Multi-Electrode Systems for Electrogenic Tissue, Methods for Their Manufacture and Uses

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This invention covers multi-probe systems designed to interface with electrically active (electrogenic) biological tissue, such as cardiac or neural tissue. The systems consist of multiple sensing and/or stimulating probes that can record electrical signals from or deliver electrical impulses to tissue simultaneously across several sites. Methods for manufacturing these multi-probe assemblies are also described, along with their intended medical applications. The technology enables more comprehensive spatial mapping and targeted stimulation of electrogenic tissue than single-probe approaches allow.

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• Cardiac electrophysiology mapping, where multiple probes simultaneously record electrical activity across different regions of the heart to locate arrhythmia sources.
• Deep brain stimulation therapy, where a multi-probe array delivers precisely targeted electrical impulses to multiple neural sites for treating conditions such as Parkinson's disease or epilepsy.
• Intraoperative neurophysiological monitoring, where multi-probe systems track electrical activity in neural tissue in real time during surgery to prevent accidental nerve damage.
• Implantable cardiac rhythm management devices that use multi-site sensing to improve detection accuracy and deliver more effective pacing or defibrillation therapy.
• Research applications in electrophysiology laboratories studying the coordinated electrical behavior of cardiac or neural tissue cultures using multi-electrode recording arrays.

BenefitsContent extracted from patent full text and abstract with AI.

• Simultaneous multi-site recording provides a more complete spatial picture of electrical activity in electrogenic tissue compared to single-probe measurements.
• Multi-probe stimulation enables more precise and targeted delivery of electrical impulses, reducing off-target effects on surrounding tissue.
• Integrated manufacturing methods ensure consistent probe geometry and electrical characteristics across all probes in the array, improving measurement reliability.
• The system's ability to both sense and stimulate at multiple locations enables closed-loop feedback therapies that can adapt in real time to changing tissue conditions.
• Multi-probe coverage reduces the need for repeated repositioning of a single probe, shortening procedure times and minimizing patient discomfort or surgical risk.

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Patent Abstract

Multi-electrode systems for electrically active tissue, methods for their manufacture and uses.