Method for Modulation of Neuronal Activity in the Brain by Means of Sensory Stimulation and Detection of Brain Activity

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The invention describes a method and device for modulating brain activity through controlled sensory stimulation (such as visual, auditory, or tactile pulses), combined with real-time detection and analysis of neuronal rhythms via EEG or MEG. By delivering specific pulse patterns at identified brain rhythm frequencies, the system can either enhance under-expressed healthy rhythms or suppress abnormal (pathological) brain rhythms. The device dynamically adjusts stimulation parameters based on feedback from brain activity measurements, enabling personalized diagnosis and therapy for functional brain disorders.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of neurological conditions with abnormal brain rhythms, such as epilepsy, Parkinson's disease, and tremor disorders.
• Cognitive rehabilitation after stroke or brain injuries to restore or improve affected functions.
• Non-invasive neuromodulation for psychiatric disorders like depression or schizophrenia.
• Research tool to study brain oscillations and their role in sensory processing or cognition.
• Sensory training for patients with sensory deficits or perceptual disorders.
• Biofeedback therapies where voluntary patient input is limited or impossible.

BenefitsContent extracted from patent full text and abstract with AI.

• Non-invasive—uses external sensory stimuli, not implanted devices.
• Personalized—adapts stimulation parameters in real-time to individual patient brain activity.
• Targets both physiological (healthy) and pathological (unhealthy) brain rhythms for broad application.
• Allows objective diagnosis and monitoring of brain function.
• Potential to treat disorders even when patient cooperation is minimal or impossible.
• Enables faster and more accurate identification of effective stimulation parameters.

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Patent Abstract

The invention relates to a method for controlled modulation of physiological and pathological neuronal rhythmic activity in the brain by means of sensory stimulation, which is capable of diagnostically ascertaining functional disorders in the brain and of alleviating or eliminating the symptoms of a functional disruption. According to the invention, the method comprises generating a plurality of pulses at a plurality of excitation frequencies, respectively, to stimulate neuronal rhythmic activity in a patient's brain; measuring the neuronal rhythmic activity in response to the pulses; determining an excitation frequency in which the measured neuronal rhythmic activity has a maximum amplitude of pathological rhythm; generating an entraining periodic pulse sequence operating at the excitation frequency; and generating a desynchronization pulse following the entraining periodic pulse sequence to desynchronize the neuronal rhythmic activity, where the pulse are either visual or acoustic or tactile.