Method for Topographical Presentation of Alterations in an Examined Brain

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This patent discloses a method for accurately mapping and visualizing structural changes or abnormalities in the human brain using volumetric imaging data such as MRI or histology. The method involves extracting detailed profiles of boundaries between functional areas in the brain, comparing microstructural features to reference brains, and aligning data from different brains using advanced algorithms that compensate for individual differences by elastic image registration. The process results in topographical maps and probability maps that improve analysis and comparison across brains.

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• Early diagnosis and monitoring of neurological disorders (e.g., Alzheimer's disease, stroke, tumors) via brain imaging.
• Research studies comparing structural brain differences across populations or over time.
• Mapping functional and structural brain areas for pre-surgical planning, especially in neurosurgery and epilepsy treatment.
• Creation of detailed brain atlases that account for individual variability in brain anatomy.
• Correlation of imaging data with behavioral or cognitive studies in neuroscience.

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• Provides objective and precise identification of boundaries between brain regions, increasing reproducibility and reliability.
• Enables robust comparison across different brains and imaging modalities by compensating for individual anatomical variability.
• Facilitates the creation of high-resolution, probabilistic maps for use in research and clinical practice.
• Supports longitudinal studies by tracking and visualizing changes in brain structure over time.
• Enhances diagnosis and treatment planning by improving the visualization and localization of functional and pathological brain regions.

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Patent Abstract

The invention relates to a method for the topographical presentation of structural alterations in an examined brain using volume data records. In line with the invention, this method is distinguished in that functional areas are mapped by extracting profiles, where the profiles record boundaries for two functional areas in the examined brain, in that the boundaries of the two functional areas are recorded by calculating a multivariant distance measurement, and in that a microstructure in the region of the boundaries of the two cortical areas is recorded and is compared with at least one microstructure in a boundary region of a reference brain. To increase the comparability of various areas in various brains taking into account the interindividual variability, it is expedient for the volume data records to be transformed to a target volume data record using an elastic registration method.