Biomarker Sensor-Based Detection of Disease-Specific Biomarkers

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention discloses highly sensitive biomarker detection sensors using plasmon-enhanced fluorescence and gold nanoparticle arrays to identify disease-specific biomarkers, particularly in body fluids such as blood. The sensors use tailored nanostructures and immobilized antibodies or aptamers specific to the disease marker, enabling strong signal amplification and high specificity, even at very low marker concentrations. The system can be integrated into kits for both laboratory and rapid, on-site diagnostic use, including point-of-care settings.

Use CasesContent extracted from patent full text and abstract with AI.

• Early detection and diagnosis of malaria and other infectious diseases by detecting disease-specific biomarkers in blood samples.
• Point-of-care diagnostic testing in remote or low-resource environments, enabling rapid screening with minimal equipment.
• Multiplex diagnostic assays for simultaneous detection of multiple diseases by targeting several biomarkers in a single assay.
• Clinical laboratory testing for quantitative measurement of biomarker levels to monitor disease progression or treatment response.
• Integration into high-throughput screening platforms (e.g., multi-well plates) for routine, automated testing in hospitals or research labs.

BenefitsContent extracted from patent full text and abstract with AI.

• Extremely high sensitivity, capable of detecting trace amounts of disease markers (down to femtomolar concentrations), surpassing conventional ELISA or rapid diagnostic tests.
• High specificity due to the use of well-oriented, disease-specific antibodies or aptamers, reducing false positives.
• Scalable and cost-effective sensor fabrication via nanolithography, suitable for mass production and automation.
• Rapid results and potential adaptation for both qualitative (yes/no) and quantitative (exact value) testing modes.
• Flexible detection principle, allowing for customization to detect virtually any biomarker by using appropriate antibodies or aptamers.
• Minimal sample pretreatment required, enabling use directly with complex fluids such as blood.
• Amenable to portable or field-deployable kits for immediate diagnostic use outside of specialized laboratory settings.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to biomarker detection sensors for detecting disease-specific biomarkers, kits based on these sensors, methods for determining disease-specific biomarkers in body fluids, and corresponding uses.