Use of Peptide Ligands of the 3CL Protease of SARS-CoV-2 for the Therapy of COVID-19

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes the use of specific peptide ligands that inhibit the 3CL protease enzyme of SARS-CoV-2, which is the virus responsible for COVID-19. These peptides, defined by certain amino acid sequences, can be used as a medicine, particularly for treating COVID-19 by blocking a critical part of the virus's replication process.

Use CasesContent extracted from patent full text and abstract with AI.

• Development of new antiviral drugs specifically targeting SARS-CoV-2.
• Treatment of COVID-19 patients to reduce disease severity or duration.
• Potential use in combination therapies with other antiviral agents.
• Prophylactic use in high-risk populations to prevent COVID-19 infection.
• Research applications for studying coronavirus replication mechanisms.

BenefitsContent extracted from patent full text and abstract with AI.

• Targets a key enzyme essential for SARS-CoV-2 replication, offering a direct antiviral effect.
• May reduce the severity, progression, or duration of COVID-19 symptoms.
• Potentially effective against different coronavirus variants that rely on the 3CL protease.
• Offers a novel therapeutic approach beyond vaccines and existing antivirals.
• Can be adapted or modified for future coronavirus outbreaks involving similar proteases.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18 and SEQ ID NO: 19 as well as homologues, fragments and parts thereof, the use thereof for inhibiting SARS-CoV-2 3CL protease, such a peptide for inhibiting SARS-CoV-2 3CL protease and such a peptide for use as a medicament, in particular for use in the treatment of COVID-19.