Device for Examining Cells Having an Elastomer, and Use of the Device

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention is a specialized device for examining living cells, made from an elastomer material (like PDMS silicone). The device features a thin, microstructured bottom and a reinforced edge, enabling precise mechanical stretching of cultured cells attached to the device. The integrated microstructures act as measurement references, allowing accurate determination of how mechanical forces and deformations are transferred to the cells during experiments. The system improves the ability to study cell responses to mechanical stress.

Use CasesContent extracted from patent full text and abstract with AI.

• Biomedical research studying how mechanical forces affect cell behavior and morphology
• Simulating physiological conditions found in tissues, such as those in blood vessels or muscles
• Drug testing and screening to observe cellular response under mechanical strain
• Development and validation of biomaterials or medical devices where cell mechanical interaction is important
• Cellular biomechanics studies, including force measurement and cell orientation under stress
• Educational settings for teaching cell mechanobiology

BenefitsContent extracted from patent full text and abstract with AI.

• Enables precise and reproducible cell stretching experiments, both statically and cyclically
• Allows accurate measurement of the mechanical forces experienced by cells
• Microstructures facilitate exact calibration and quantification of deformation and force transfer
• Supports both uniaxial and, by design modifications, biaxial stretching with cost savings over traditional systems
• Reduces risk of device failure thanks to reinforced edges and innovative mounting design
• Compact and compatible with standard lab equipment like incubators and microscopes
• Supports advanced experiments, such as simultaneous force and deformation analysis of cells
• Improves reliability and interpretation of cell mechanics data compared to prior art

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Inventors & Applicants

Patent Abstract

The invention relates to a device for examining cells and having an elastomer, and to the use of said device. The elastomer (1) has a bottom (2, 3) and a thicker edge area (4, 6, 8), and regular microstructures are arranged in the bottom (3). Such elastomers are particularly suitable for stretch tests, in particular of the uniaxial type. The invention further relates to advantageous uses of such devices.