Device for the desynchronization of neuronal brain activity

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This invention is a medical device designed to desynchronize abnormal, synchronized brain activity in neurological conditions such as Parkinson’s disease, tremors, dystonia, epilepsy, and certain psychiatric disorders. The device uses multiple electrodes implanted in the brain to deliver precisely timed electrical stimulation. Unlike traditional deep brain stimulation, which continuously suppresses activity, this device delivers phase-shifted stimuli to different brain regions in a coordinated manner, disrupting pathological synchrony and restoring more natural brain patterns without extensive pre-calibration or high energy consumption.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of Parkinson’s disease for patients with drug-resistant motor symptoms such as tremor and rigidity.
• Alleviation of essential tremor and other movement disorders by breaking up abnormal brain rhythms.
• Management of dystonia through targeted desynchronization of affected neural circuits.
• Suppression of seizure activity in drug-resistant epilepsy by desynchronizing transient pathological synchrony.
• Treatment of obsessive-compulsive and related psychiatric disorders linked to pathological brain synchrony.
• Intraoperative mapping and optimization of electrode placement during neurosurgical implantation procedures.

BenefitsContent extracted from patent full text and abstract with AI.

• Reduces or avoids the need for lengthy and complex calibration procedures, enabling more rapid and effective therapy.
• Requires less electrical energy than conventional continuous stimulation, extending battery life and reducing re-implantation surgeries.
• Minimizes side effects and collateral tissue damage compared to standard high-frequency continuous stimulation.
• Adaptable to both constant and fluctuating pathological frequencies, making it suitable for intermittent disorders like epilepsy.
• Enables real-time adjustment and optimization of therapy during surgery, improving the precision of electrode placement and clinical outcomes.
• Facilitates more natural brain activity by reducing pathological synchrony instead of merely suppressing neuronal firing.

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Patent Abstract

A device for desynchronizing neuronal brain activity involving a neuron population firing in a synchronized manner at a pathological frequency. The device includes an electrode configured to generate stimuli that stimulate the neuron population; and a control unit configured to control the electrode to generate the stimuli in sequence, wherein the stimuli succeed each other with a predetermined frequency f. The predetermined frequency f is substantially equal to g×n/m, where g is the pathological frequency, and n and m are integers.