Composition for the Production of Anti-Amyloid Beta-Peptide Antibodies with D-Peptides

Simple SummaryContent extracted from patent full text and abstract with AI.

The invention describes a composition containing D-peptides (retro-inverso peptides) or antibodies that target amyloid beta peptides, which are implicated in diseases such as Alzheimer's. These specially designed D-peptides or antibodies either bind directly to the amyloid beta peptide or to domains responsible for the peptide's aggregation. The composition can be used therapeutically or preventively to induce an immune response that clears or neutralizes amyloid beta, with reduced risk of harmful immune reactions compared to traditional immunization approaches.

Use CasesContent extracted from patent full text and abstract with AI.

• Therapeutic treatment for Alzheimer's disease by preventing or clearing amyloid beta aggregations in the brain.
• Preventive vaccination for individuals at risk of developing Alzheimer's or other amyloid-related diseases.
• Diagnosis of Alzheimer's by detecting amyloid beta peptides or related biomolecules in tissues or cells.
• Potential treatment for other protein aggregation diseases such as Parkinson's, frontotemporal dementia, amyotrophic lateral sclerosis (ALS), cystic fibrosis, certain types of diabetes, and some epilepsies.
• Use in research for studying amyloid aggregation and developing new anti-aggregation therapies.

BenefitsContent extracted from patent full text and abstract with AI.

• Reduced risk of T-cell-mediated autoimmune side effects, as D-peptides are less likely to trigger these immune responses.
• Capable of inducing a strong, antibody-mediated (B-cell) immune response specifically targeting harmful amyloid beta aggregates.
• Potentially safer and more efficient than existing active immunization strategies for amyloid-related diseases.
• Lower doses required due to slower degradation and higher stability of D-peptides compared to conventional peptides.
• Versatile platform adaptable for other protein aggregation diseases beyond Alzheimer's.
• Enables both therapy and diagnosis, allowing for early detection and intervention in amyloid-related conditions.

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Inventors & Applicants

Patent Abstract

The present invention relates to a composition comprising D peptides or antibodies for use as a therapeutic agent and/or for preventing illnesses, wherein a) the D peptides interact with an amyloid peptide and b) the antibodies bond to the D peptide from a) and also to the amyloid peptide from a).