Use of Lactobacillus Buchneri for Increasing the Fertility of a Female Mammal

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This patent describes a novel use of the probiotic bacterium Lactobacillus buchneri for increasing the fertility of female mammals, especially those suffering from subclinical endometritis (a condition of uterine lining inflammation without visible symptoms). The invention involves intrauterine application of L. buchneri, which improves reproductive outcomes by shortening the time between calving and successful impregnation, reducing the number of artificial inseminations needed, and promoting uterine health. Additionally, L. buchneri can be included in sperm preparations to enhance sperm motility and further fertility outcomes, all without requiring antibiotic treatments.

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• Fertility improvement in dairy cows, pigs, horses, and other female livestock with subclinical endometritis to increase productivity and reduce economic loss.
• Probiotic-based, non-antibiotic treatments for reproductive tract health in animals, reducing reliance on antibiotics.
• Inclusion of L. buchneri in sperm preparations used for artificial insemination to enhance fertility results and sperm motility.
• Overall reproductive management programs in livestock farms aiming to optimize breeding efficiency and animal health.

BenefitsContent extracted from patent full text and abstract with AI.

• Non-antibiotic method: Reduces antibiotic use, lowering resistance risks and protecting food safety (no required withdrawal times for meat/milk).
• Increases fertility: Shortens non-productive intervals after birth (up to 90 days reduction observed in cows with subclinical endometritis) and decreases the number of inseminations needed.
• Improves uterine health: Restores normal microbial flora and addresses inflammation even before clinical symptoms appear.
• Cost-effective: Leads to more efficient breeding, reduced veterinary costs, shorter intervals between pregnancies, and higher milk and meat production for farmers.
• User-friendly: L. buchneri can be included in regular reproductive procedures (e.g., mixed with sperm in insemination) without extra treatment steps.
• Safe: No observed negative side effects and approved with zero withdrawal periods for animal products.

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Patent Abstract

The invention relates to the novel medical indication for the use of Lactobacillus buchneri for increasing the fertility of a female mammal by intra-uterine application of the Lactobacillus buchneri, the mammal having sub-clinical endometritis characterised by a lack of clinical symptoms of endometritis and a proportion of polymorphonuclear neutrophil granulocytes of greater than 5 % of the total number of cells in a smear of endometrial cells of the mammal. The invention also relates to the use of Lactobacillus buchneri as a constituent of a sperm preparation and to a sperm preparation of this type.