Nanoparticle, method for producing a nanoparticle, nanoparticle system and its use

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention discloses crosslinked polyglycerol-based nanoparticles with mean diameters typically greater than 10 nm (often 20-200 nm), along with efficient methods for their synthesis using miniemulsion or microemulsion techniques. These nanoparticles feature a highly branched, dendrimer-like structure and can encapsulate or conjugate a wide range of substances, such as drugs, dyes, catalysts, and biomolecules. The patent covers the particles themselves, compositional systems including active payloads, and detailed manufacturing processes.

Use CasesContent extracted from patent full text and abstract with AI.

• Targeted drug delivery systems for pharmaceutical applications, especially for tumor or inflamed tissue via the EPR effect
• Carriers for diagnostic imaging agents or biomarkers in medical imaging
• Encapsulation and controlled release of dyes, pigments, or fluorescent markers for bioimaging and sensor applications
• As biocompatible additives or carriers in cosmetics (creams, coatings, lubricants)
• Scaffold materials for enzymes, catalysts, or proteins in biochemistry and industrial processes
• Replacement for polyethylene glycol (PEG) or dextran in various biomedical and industrial formulations
• Nanocarriers for light harvesting substances or nanoparticles for photonic devices

BenefitsContent extracted from patent full text and abstract with AI.

• Produced from inexpensive and abundant starting materials (e.g., glycerol, glycidyl glycerolether) making them cost-effective
• Simple and scalable production methods (emulsification and crosslinking), adaptable for large-scale manufacture
• Highly tunable nanoparticle size (typically 20-200 nm, with narrow size distributions) suitable for specific applications
• High biocompatibility, making them suitable for medical and biological use
• Ability to encapsulate or attach a wide variety of substances (from small molecules to proteins and dyes) either chemically or physically
• Controlled and triggered release possible (e.g., release in reducing environments via disulfide linkers)
• Offer an alternative to PEG and dextran, with potentially improved or differentiated properties such as lower toxicity, better encapsulation or release profiles
• Stability in aqueous and some organic environments, as well as prolonged suspension stability

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to crosslinked polyglycerol based nanoparticles having a size of more than 10 nm. The invention further relates to a method of preparing such nanoparticles and to their use.