T. Suis Excretory/secretory Products and Methods of Their Use

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes isolated and recombinant biologically active polypeptides secreted by the parasitic worm Trichuris suis (T. suis). These excretory/secretory proteins, collected from the larval stage, can be produced without using live worms or their eggs, and have the ability to modulate the immune system in mammals, including humans. The patent includes pharmaceutical compositions containing these proteins and methods for using them to treat or regulate conditions involving improper immune system activity, such as inflammatory, allergic, or autoimmune disorders.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of autoimmune diseases such as Crohn's disease and ulcerative colitis by dampening abnormal immune responses.
• Therapy for allergic diseases, including asthma and allergic airway inflammation, by reducing inflammation and allergic overreaction.
• Potential treatment for other Th1/Th2-mediated disorders, such as multiple sclerosis.
• Development of pharmaceutical products that modulate immune responses without the need to administer live helminths (worms) or their ova.
• Research applications to study immunomodulation and to develop new therapies for immune-mediated diseases.

BenefitsContent extracted from patent full text and abstract with AI.

• Avoids the need to expose patients to live parasites or their eggs, which improves safety and patient compliance.
• Can specifically modulate immune pathways (Th1/Th2) and key cytokines, potentially offering targeted treatment of immune disorders.
• May reduce side effects compared to broad immunosuppressive therapies, as these proteins can fine-tune the immune response.
• Provides a platform for developing new biologic drugs for difficult-to-treat inflammatory and autoimmune conditions.
• Supports the development of non-live, standardized, and reproducible therapies with defined active molecular components.

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Inventors & Applicants

Patent Abstract

Helminthic excretory/secretory products are disclosed herein, which include biologically active polypeptides secreted by Trichuris suis. Such products are useful for modulating an immune response of a subject or in the treatment of certain medical disorders, including those that are Th1- and/or Th2-mediated medical disorders.