Fluorine-containing Compounds for Use as Nucleophilic Reagents for Transferring Functional Groups onto High Value Organic Compounds

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This patent discloses new fluorine-containing organic compounds that act as nucleophilic reagents for transferring trifluoromethylthio (SCF3), perfluoroalkylthio, and related groups onto valuable organic molecules. Unlike existing reagents, these compounds do not require expensive metals, are stable solids, and can be easily synthesized and handled. They allow the direct installation of fluoroalkyl-containing thiol, selenyl, or alkoxy groups onto pharmaceuticals and other high-value targets, improving process efficiency and expanding options in advanced organic synthesis.

Use CasesContent extracted from patent full text and abstract with AI.

• Synthesis of SCF3-containing pharmaceuticals to enhance drug potency and membrane permeability.
• Creation of agrochemicals with increased bioactivity and stability.
• Preparation of specialty chemicals with improved physicochemical properties for material science.
• In-lab or industrial functionalization of alcohols and other substrates with trifluoromethylthio or perfluoroalkylthio groups.
• Catalytic generation of SCF3-metal species for further synthetic transformations.

BenefitsContent extracted from patent full text and abstract with AI.

• Metal-free, organic reagents reduce costs and avoid the hazards of toxic metals/gases.
• Bench-stable solids that are easy and safe to store and handle.
• Simple, two-step synthesis from cheap and widely available starting materials.
• Enable direct functional group transfer without need for extensive precursor modification.
• Facilitate the rapid screening and development of fluorinated compounds in drug discovery.
• Allow for more scalable, green, and practical processes in both research and industry.

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Patent Abstract

The present invention relates to a compound of general formulae (I)for use as reagents in trifluoromethylthiolation reactions.