Pharmaceutical Composition for the Diagnosis or Treatment of Diseases Associated with Zinc Finger Proteins

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention describes pharmaceutical and diagnostic compositions that contain specific nucleic acids (aptamers) capable of binding to zinc finger motifs found in many zinc finger proteins, such as the human glioblastoma oncogene protein and ZFY protein. These compositions can selectively detect or inhibit zinc finger proteins, making them useful for diagnosing or treating diseases, particularly glioblastoma, by targeting these proteins with high affinity and specificity.

Use CasesContent extracted from patent full text and abstract with AI.

• Early diagnosis of glioblastoma and other diseases associated with abnormal zinc finger protein expression using blood or tissue samples.
• Therapeutic treatment to slow or inhibit tumor growth and recurrence in glioblastoma patients by targeting the glioblastoma oncogene protein.
• Development of diagnostic test kits and sensors for detecting zinc finger proteins in clinical samples.
• Research tools for isolating and purifying zinc finger proteins from biological samples.
• Monitoring disease progression or response to therapy in patients with disorders involving zinc finger proteins.

BenefitsContent extracted from patent full text and abstract with AI.

• Highly selective and sensitive detection of zinc finger proteins, improving diagnostic accuracy and enabling early disease identification.
• Potential to slow tumor progression and reduce recurrence, especially in glioblastoma, by inhibiting relevant oncogenic proteins.
• Versatile application in both diagnosis and therapy (theranostics).
• Minimized risk of false positives/negatives due to high specificity of aptamers for zinc finger motifs.
• Can be incorporated into different delivery forms (oral, injectable, etc.) and assay platforms, facilitating clinical and research use.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to nucleic acids which bond to zinc finger proteins, for example human ZFY protein or human glioblastoma oncogene protein and to the uses of said acids.