Zwitterionic Pillararene Derivative

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention discloses a new class of antimicrobial compounds called zwitterionic pillararene derivatives. Unlike previous macrocyclic molecules, these derivatives possess both positive and negative charges, making them zwitterionic. These compounds and their nanoparticles demonstrate strong antibacterial activity against a broad spectrum of bacteria, including Gram-positive, Gram-negative, and drug-resistant strains. Notably, they can effectively inhibit and even destroy established bacterial biofilms, even at very low concentrations, and are more effective than common antibiotics like ampicillin in this role. The invention encompasses the chemical structures, methods of synthesis, applications as coatings or medicaments, and incorporation into articles such as medical devices.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of bacterial infections, including those caused by drug-resistant bacteria in humans or animals
• Destruction or inhibition of bacterial biofilms on medical devices (e.g., catheters, stents, implants) to prevent hospital-acquired infections
• Coating of surfaces in clinical settings, laboratories, or food processing environments to provide long-term antibacterial and anti-biofilm protection
• Incorporation into wound dressings, bandages, or surgical tools to reduce infection risk
• Development of new medicaments for topical or in vivo use targeting biofilm-associated infections
• Integration into filtration membranes or packaging materials to maintain sterility and prevent contamination
• Industrial applications where biofilm buildup on equipment is problematic, such as water treatment or dairy processing

BenefitsContent extracted from patent full text and abstract with AI.

• Broad-spectrum antibacterial activity effective against both Gram-positive and Gram-negative bacteria, including drug-resistant strains
• Highly effective in killing bacteria within mature biofilms, which are typically resistant to conventional antibiotics
• Active at extremely low concentrations, reducing potential toxicity and cost
• Reduced risk for the development of bacterial resistance as compared to traditional antibiotics
• Can be incorporated as coatings or embedded in a wide variety of substrates or articles, allowing versatile application
• Prolonged and durable antibacterial effects, even after extended periods of exposure
• Can be manufactured through relatively simple, scalable synthetic routes
• Applicable both in vitro (e.g., coatings, filters) and in vivo (e.g., medical treatments, implants)

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a zwitterionic pillararene derivative having a structure according to the following general formula:Thereby, residue R is a zwitterionic hydrocarbon chain. The invention further relates to uses of such zwitterionic pillararene derivative, to products comprising such zwitterionic pillararene derivative, and to a method for manufacturing such zwitterionic pillararene derivative.