Substituted 6-Anilinopurine Derivatives as Inhibitors of Cytokinin Oxidase/dehydrogenase and Preparations Containing These Derivatives

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention discloses a new group of chemical compounds—substituted 6-anilinopurine derivatives—which act as potent inhibitors of the enzyme cytokinin oxidase/dehydrogenase. These compounds are tailored to precisely regulate cytokinin levels in cells, leading to effects such as delayed senescence, enhanced proliferation, and improved growth. The invention includes detailed preparation methods and covers their use in formulations for agricultural, pharmaceutical, cosmetic, and cell culture applications.

Use CasesContent extracted from patent full text and abstract with AI.

• Agriculture: Promoting plant growth, increasing crop yield and quality, delaying plant cell senescence, stimulating tissue culture proliferation, hybrid seed production, and improving post-harvest freshness.
• Cosmetics: Developing anti-aging skin creams, gels, and ointments to delay senescence of skin cells and maintain youthful skin appearance.
• Pharmaceuticals: Formulating treatments to delay mammalian cell aging, support tissue regeneration, and possibly regulate immune responses (e.g., transplant rejection or autoimmunity).
• Biotechnology: Enhancing the efficiency of plant and mammalian cell cloning, as well as embryonic development (e.g., oocyte cloning).
• Cell culture: Stimulating proliferation and morphogenesis in tissue or microbial cultures for research or production purposes.
• Horticulture and ornamentals: Improving the quality and shelf-life of decorative plants and flowers.

BenefitsContent extracted from patent full text and abstract with AI.

• Significantly delays cellular senescence in both plants and animal (human) cells, enhancing longevity and vitality.
• Enhances proliferation and morphogenesis, especially in tissue and cell cultures, leading to more efficient propagation.
• Boosts agricultural productivity by increasing crop yield and quality, with application to a wide range of crops.
• Reduces toxicity and improves selectivity compared to conventional cytokinins—safe for cells at effective doses.
• Versatile formulation options (creams, gels, powders, granules, emulsions) for a variety of practical uses in different industries.
• Potential to support anti-aging, regenerative, and immune-suppressive therapy in medicine.
• Non-mutagenic and exhibits low cytotoxicity, making these compounds safer for widespread use.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to substituted 6-anilinopurine derivatives of the general formula I, wherein R denotes one to five substituents independently selected from the group consisting of hydrogen, halogen, hydroxyl, amino, alkyloxy and alkyl group, and R2 denotes amino, halogen, nitro, thio, alkylthio or alkyl group for use as inhibitors of cytokinin oxidase/dehydrogenase. The invention also relates to the compositions containing these derivatives.