Peptide with Antimicrobial Activity

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention relates to a novel class of synthetic peptides with antimicrobial activity. These peptides are designed with specific sequences and modified amino acids, including fluorinated and non-natural residues, to enhance their stability, effectiveness, and selectivity against a wide range of bacterial (both Gram-positive and Gram-negative, including resistant strains) and fungal pathogens. The peptides demonstrate improved proteolytic stability, low toxicity, and minimal side effects on human or animal cells.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of bacterial infections in humans, especially those caused by antibiotic-resistant strains such as MRSA, E. coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae.
• Therapeutic application for fungal infections, including those caused by Candida albicans.
• Inclusion in topical treatments (creams, gels) for skin infections.
• Use as a preservative or disinfectant in medical devices or surfaces to reduce microbial contamination.
• Potential use in veterinary medicine to treat animal infections.
• Development of coatings for medical implants to prevent infection.
• Addition to wound care dressings to reduce risk of infection.

BenefitsContent extracted from patent full text and abstract with AI.

• Broad-spectrum antimicrobial activity, effective against both Gram-positive and Gram-negative bacteria as well as fungi.
• Active against antibiotic-resistant and multi-drug-resistant bacterial strains.
• Improved stability against enzymatic (proteolytic) degradation, increasing their lifespan and effectiveness in vivo.
• Low cytotoxicity and minimal hemolytic activity, making them safer for therapeutic use.
• Fluorination and specific structural features allow tunable hydrophobicity to optimize membrane-disrupting activity while minimizing toxicity.
• Potential to address the growing problem of antibiotic resistance with a novel mode of action.
• Synthesized by solid-phase peptide synthesis, enabling scalable and reliable manufacturing.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention refers to a peptide with antimicrobial activity comprising the following sequence        Y1-[R-X1-R-X2-R-dL-dF-[2]Abz-dA-R-X2-R-X1-R]-Y2Wherein R is D-or L- Arginine or an Arginine analogue, dL is D-Leucine, dF is D-Phenylalanine, [2]Abz is 2-Aminobenzoic acid, dA is D-Alanine, X1 is FaHbC - (FcHdC)n -CH2-CHNH2CO2H, wherein a is 0,1, 2, 3; b is 0, 1, 2, 3; wherein the sum of a and b is always 3; c is 0, 1, 2; d is 0, 1, 2; wherein the sum of c and d is always 2; Wherein n is 0-5, X2 is L-Tryptophan (W), D-Tryptophan or a Tryptophan analogue or X1, Y1 is Acetyl or H or any suitable protective group; and Y2 is NH2 or OH or any suitable protective group.