Bismuth-Containing Composition for Reducing Phosphate Concentration in Liquids

Simple SummaryContent extracted from patent full text and abstract with AI.

The invention describes a bismuth-containing composition designed to reduce the concentration of inorganic phosphate in fluids, particularly body fluids and dialysis fluids. Unlike traditional phosphate binders that use calcium or aluminum (which can have significant side effects), this approach uses bismuth compounds, which have higher affinity for phosphate and offer safer and potentially more effective management of elevated phosphate levels, notably in patients with kidney disease or those undergoing dialysis.

Use CasesContent extracted from patent full text and abstract with AI.

• Treating hyperphosphatemia (high phosphate levels) in patients with chronic kidney disease, especially those on dialysis.
• Reducing phosphate concentration in blood plasma during hemodialysis or peritoneal dialysis procedures.
• Developing oral medications (tablets, suspensions, or solutions) for managing excess phosphate absorption from the diet.
• Potential use in other clinical situations requiring phosphate reduction in biological fluids.

BenefitsContent extracted from patent full text and abstract with AI.

• Safer alternative to traditional phosphate binders, avoiding aluminum neurotoxicity and calcium-induced vascular calcification.
• Greater efficacy at lower doses due to bismuth's high affinity for phosphate ions.
• Reduced dialysis time required to maintain healthy phosphate levels in patients.
• Minimized risk of toxic accumulation because bismuth is efficiently eliminated during dialysis or fecal excretion.
• Cost-effective and practical dosing regimens, facilitating patient compliance.
• Flexible formulation options (tablets, suspensions, solutions) for varied clinical needs.

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Inventors & Applicants

Patent Abstract

The present invention relates to a bismuth-containing composition for reducing the concentration of inorganic phosphate in fluids, in particular body fluids or dialysis fluids.