Means and Methods for Treating Bacterial Infections

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent discloses novel synthetic peptides (with precisely defined amino acid sequences) and their use—alone or in combination with known antibiotics—for treating bacterial infections, especially those caused by multi-resistant bacteria. The inventions include compositions and methods for applying these peptides topically or systemically to treat infections such as skin infections, wound infections, sepsis, and also to promote wound healing. The peptides can be used alone, in synergistic combinations, or together with antibiotics to provide enhanced antibacterial activity, including activity against biofilms on medical devices and hospital surfaces.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of multidrug-resistant bacterial infections, such as MRSA, Pseudomonas aeruginosa, and others.
• Topical treatment of skin and wound infections, including chronic, hard-to-heal wounds.
• Prevention and treatment of sepsis and other serious systemic bacterial infections.
• Adjunct therapy in combination with known antibiotics to enhance efficacy and combat antibiotic resistance.
• Prevention or removal of bacterial biofilms on medical devices (e.g., catheters, implants) and hospital surfaces.
• Treatment of infections associated with chronic conditions, such as COPD and cystic fibrosis.
• Promotion of wound healing, even in cases resistant to conventional therapies.

BenefitsContent extracted from patent full text and abstract with AI.

• Effective against a broad spectrum of bacteria, including multi-resistant strains.
• Demonstrates synergistic activity when combined with other peptides or antibiotics, allowing for lower doses and potentially reducing side effects and resistance development.
• Can be used both topically and systemically, increasing versatility of treatment.
• Reduces and removes bacterial biofilms, addressing a major challenge in healthcare settings.
• Promotes wound healing in addition to treating infection, providing dual therapeutic effects.
• Shown to neutralize endotoxins and modulate inflammation, which can be crucial for treating sepsis and chronic wounds.
• Potential to prolong the usefulness of existing antibiotics by restoring their efficacy against resistant bacteria.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a pharmaceutical composition comprising or consisting of a combination of (a) two or more peptides, each peptide consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking; (23) G or lacking; or (b) one or more peptides, each peptide consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11 ) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking; (23) G or lacking, and one or more antibiotics selected from small organic molecule antibiotics such as ceftriaxone, oxacillin, amoxicillin, amikacin, ciprofloxacin, erythromycin, imipenem and tetracycline, and peptidic antibiotics such as daptomycin and vancomycin.