Nanoparticles Functionalized with Dendritic Polyglycerol Sulfate

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes nanoparticles with an inorganic core (such as gold or iron oxide) coated with a shell made from dendritic polyglycerol sulfate (dPGS) attached through a special linker. The dPGS structure is highly branched and functionalized with sulfate groups, which gives the nanoparticles a strong and selective affinity for certain proteins (selectins) involved in inflammation. These nanoparticles can be used directly or combined with drugs or imaging molecules for targeted medical applications, especially in the diagnosis and treatment of inflammatory diseases.

Use CasesContent extracted from patent full text and abstract with AI.

• Targeted delivery of anti-inflammatory drugs to sites of inflammation for diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, psoriasis, asthma, and transplant rejection.
• Use of the nanoparticles as contrast agents for imaging modalities like MSOT (Multispectral Optoacoustic Tomography), MRI, PET, SPECT, or fluorescence imaging to diagnose and localize inflammatory lesions.
• Selective inhibition of selectin-mediated leukocyte adhesion, reducing tissue damage in chronic or acute inflammatory conditions.
• In vitro applications such as affinity purification, ELISA, or biomolecule capture in research or diagnostics by immobilizing the nanoparticles on surfaces or matrices.
• Transport and controlled release of other therapeutic or diagnostic agents by conjugation to the dPGS shell.

BenefitsContent extracted from patent full text and abstract with AI.

• Highly specific targeting of inflamed tissues through high affinity binding to selectins, reducing off-target effects and improving treatment precision.
• Reduced need for additional targeting molecules (like antibodies), simplifying synthesis and lowering costs.
• Excellent biocompatibility and low toxicity, given the benign nature of both the inorganic core (e.g., gold, iron oxide) and dendritic polyglycerol sulfate.
• Strong inhibition of selectin-mediated immune cell recruitment, potentially leading to superior anti-inflammatory effects compared to existing technologies.
• Versatile platform suitable for both therapeutic payload delivery and diagnostic imaging applications, including direct use as imaging contrast medium.
• Simple and flexible chemical synthesis, allowing for customization of linker structures, shell thickness, and functionalization with drugs or signals.

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Patent Abstract

The invention relates to nanoparticles, characterized by a) a core consisting of an inorganic material and b) a shell consisting of a linker and dendritic polyglycerol sulfate, wherein the polyglycerol sulfate consists of repeated glycerol units of formula (RO-CH2)2CH-OR, where R = H or other glycerol units, and one or more OH groups of the glycerol units are replaced by sulfate groups of formula -OSO3X, where X is equal to H, by an alkali metal atom, such as Li, Na or K, or by an ammonium ion, and wherein the linker links the polyglycerol sulfate and the core to each other. The nanoparticles are suitable for medical uses, for example, for the diagnosis and treatment of inflammatory diseases.