Nanoparticles functionalized with sulfated amino alcohols for the inhibition of selectin-mediated cell adhesion

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention describes gold nanoparticles that are functionalized with sulfated amino alcohols, which specifically inhibit the adhesion of cells mediated by selectins—key proteins involved in inflammatory responses. By targeting selectin-ligand interactions, these nanoparticles can disrupt the recruitment of white blood cells to sites of inflammation, offering a novel approach for treating inflammatory diseases. The nanoparticles are designed to be stable, non-toxic, and highly effective at very low concentrations.

Use CasesContent extracted from patent full text and abstract with AI.

• Development of therapeutic agents for chronic inflammatory diseases such as rheumatoid arthritis, asthma, and psoriasis.
• Treatment of acute inflammatory conditions, including ischemia-reperfusion injuries and graft rejection after organ transplantation.
• Selective inhibition of leukocyte adhesion in vascular diseases.
• Potential research tool for studying selectin-mediated cell interactions in biology and medicine.

BenefitsContent extracted from patent full text and abstract with AI.

• Significantly higher affinity and inhibition potency for selectins compared to existing inhibitors (active at very low picomolar concentrations).
• Potential to treat a broad range of inflammatory diseases by targeting a common adhesion mechanism.
• Nanoparticles are stable, non-toxic to living cells, and maintain their activity and structure in physiological environments.
• Nanoparticle synthesis is straightforward, supporting scalability and reproducibility for pharmaceutical applications.
• Reduced side effects expected due to targeted mode of action (disrupts specific molecule interactions rather than broad immune suppression).

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Inventors & Applicants

Patent Abstract

The present invention relates to functionalized nanoparticles inhibiting selectin-mediated cell adhesion and their use as anti-inflammatory therapeutics. More specifically, said functionalized nanoparticles comprise a core, formed by gold, a shell coating said core, formed by a monolayer of a linker molecule, and an acyclic or carbocyclic sulfated amino alcohol linked to said linker molecule via a peptide bond.