Use of Polygonatum Cyrtonema HUA. Lectin in Blocking Invasion and Infection of Novel Coronavirus

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes the use of a lectin protein derived from Polygonatum cyrtonema Hua. (PCL) to block the entry and infection of SARS-CoV-2 (the virus responsible for COVID-19) and its variants by specifically binding to glycan chains on the viral spike protein. By targeting the conserved sugar structures rather than variable protein domains, PCL can prevent the virus from attaching to and entering host cells. The invention includes a pharmaceutical composition and kit based on PCL for prophylactic or therapeutic use against COVID-19.

Use CasesContent extracted from patent full text and abstract with AI.

• Development of preventive drugs to block infection by SARS-CoV-2 and its variants (e.g., Delta, Omicron, etc.)
• Therapeutic treatment for individuals already infected with COVID-19 to reduce viral replication and spread
• Formulation of pharmaceutical compositions (e.g., nasal sprays, oral drugs) containing PCL for public health applications
• Inclusion of PCL as an adjunct therapy in combination with other anti-COVID-19 drugs
• Development of diagnostic kits or research reagents to study coronavirus spike glycan interactions

BenefitsContent extracted from patent full text and abstract with AI.

• Effective against multiple SARS-CoV-2 variants, addressing immune escape and reduced vaccine efficacy issues
• Targets conserved glycan structures, making activity less affected by spike protein mutations
• Can block viral entry at an early stage, potentially reducing infection severity and transmission
• May be used both for prevention and treatment, offering flexibility in medical use
• Based on a natural protein from traditional Chinese medicine, potentially offering good biocompatibility and safety profile

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Inventors & Applicants

Patent Abstract

The present application provides a novel blocking method for blocking the invasion and infection of SARS-CoV-2 by using polygonatum cyrtonema Hua. lectin protein, use thereof, and a pharmaceutical composition and kit for blocking the invasion and infection of SARS-CoV-2.