Micellar Composition from an Amphiphilic Copolymer for Tumor Therapy

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention discloses a new amphiphilic copolymer that self-assembles into micelles, specifically designed for the targeted delivery of anti-tumor drugs. The copolymer consists of a hydrophilic dendritic polyglycerol sulfate/sulfonate block, a hydrophobic biodegradable polymer block (like polycaprolactone, polylactic acid, or PLGA), and a specialized linker that is stable in circulation but cleavable inside the tumor environment due to specific triggers (such as changes in redox potential or pH). These micelles can encapsulate hydrophobic drugs and release them selectively at tumor sites, improving drug stability, reducing side effects, and increasing therapeutic efficacy.

Use CasesContent extracted from patent full text and abstract with AI.

• Targeted delivery of chemotherapeutic drugs to tumors, reducing exposure to healthy tissues.
• Encapsulation and controlled release of diagnostic agents for tumor imaging or monitoring.
• Carrying nucleic acids (like siRNA) or proteins for gene therapy or other advanced therapeutic modalities.
• Potential as a delivery vehicle for vaccines or immunotherapies specific to cancer.
• Formulation of poorly water-soluble drugs to enhance their clinical bioavailability and stability.

BenefitsContent extracted from patent full text and abstract with AI.

• Improved drug stability during blood circulation with minimal premature drug release.
• Selective and responsive drug release at tumor sites via redox or pH-sensitive linker, reducing systemic toxicity.
• Efficient encapsulation of hydrophobic drugs, expanding the range of drugs that can be delivered.
• Reduced side effects and higher safety profile compared to non-targeted or unstable formulations.
• Cost-effective and scalable synthesis route, suitable for industrial and clinical application.
• Micelles can be stored in dried form and resuspended, overcoming stability limitations of other systems.
• Biocompatible and biodegradable components, supporting safe in vivo use.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to an amphiphilic copolymer comprising a first block, a second block and a linker covalently linking the first block with the second block, wherein the first block is a hydrophilic dendritic polyglycerol derivative having a polyglycerol backbone and carrying a plurality of sulfate or sulfonate residues substituting hydroxyl groups of the polyglycerol backbone, wherein the second block is a hydrophobic block comprising a polymer chosen from the group consisting of polycaprolactone, a polylactic acid polymer, and a copolymer of lactic acid and glycolic acid. The linker comprises a hydrocarbon having at least six consecutive methylene residues and a cleavable entity. The linker is devoid of a triazole-containing residue resulting from a reaction between an alkyne and an azide.