Divalent metal-ion loaded nano-transport system having a dendritic architecture useful for therapy

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This invention relates to specialized nanocarriers with a dendritic (branched) structure designed to encapsulate and transport divalent metal ions, such as copper (Cu) and zinc (Zn(II)), using non-covalent interactions. These nanocarriers can efficiently deliver metal ions into specific cells and tissues, bypassing normal cellular uptake mechanisms. They are particularly useful in pharmaceutical compositions to address metal-ion deficiencies and related disorders, including neurodegenerative diseases like Alzheimer's and Menkes disease.

Use CasesContent extracted from patent full text and abstract with AI.

• Targeted delivery of copper or zinc ions to specific tissues for therapy.
• Treatment of copper transport disorders, such as Alzheimer's disease and Menkes disease.
• Pharmaceutical compositions for slowing down biological ageing.
• Research tool for studying cellular uptake and distribution of metal ions.
• Potential use in other metal-ion deficiency or imbalance disorders.
• Possible use in nanotechnology-based drug delivery platforms for other bioactive agents by modifying the nanocarrier's payload.

BenefitsContent extracted from patent full text and abstract with AI.

• Efficient and controlled delivery of divalent metal ions to target cells or tissues.
• Bypasses limitations of normal cellular metal-ion uptake, enabling higher local concentrations where needed.
• Non-covalent encapsulation reduces risk of toxicity from free metal ions in the body.
• Versatile nanocarrier design allows tuning for different payloads and targeting needs.
• Potential for improved treatment outcomes in neurodegenerative and metal-ion transport disorders.
• Can be formulated for various pharmaceutical administration routes (oral, injectable, etc.) and adaptable to patient needs.

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Patent Abstract

Described is the use of a nanocarrier having a dendritic structure which is composed of a dendritic core and at least one shell for the non-covalent encapsulation and/or transport of divalent metal-ions, preferably Cu-ions or Zn(II)-ions. Also described is a pharmaceutical composition containing such nanocarrier complexed divalent metal-ions in a non-covalent encapsulated form. Finally several therapeutic uses of such a nanocarrier divalent metal-ion complex are described, for example for slowing down ageing or for the treatment of Cu-ion transport disorders like Alzheimer's disease (AD) or Menkes disease.