Linear-Dendritic Polyglycerol Compounds, Methods for Their Preparation and Their Use

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes a new class of linear-dendritic polyglycerol compounds that can self-assemble into well-defined, uniform micellar structures in water. These compounds are specifically designed to encapsulate and solubilize hydrophobic (water-insoluble) substances, making them highly effective as carriers for drugs, dyes, and diagnostic molecules. The patent covers both the chemical structure, synthesis methods (notably click chemistry), and various applications for these water-soluble, biocompatible nanotransporters.

Use CasesContent extracted from patent full text and abstract with AI.

• Solubilizing poorly water-soluble pharmaceuticals to enhance their bioavailability in medical treatments.
• Serving as nanocarriers for targeted delivery of drugs, especially anticancer agents, to improve efficacy and reduce side effects.
• Encapsulating imaging agents or dyes for medical diagnostics (e.g., MRI, IR imaging) and bioimaging.
• Stabilizing emulsions, micro- and nanoemulsions, and foams for use in pharmaceuticals, cosmetics, or food industries.
• Encapsulating catalysts or forming microreactors for chemical synthesis and nanotechnology applications.
• Coating or stabilizing metal nanoparticles for use in sensors, catalysis, or advanced materials.

BenefitsContent extracted from patent full text and abstract with AI.

• Significantly increases the water solubility of hydrophobic drugs and markers, improving bioavailability.
• Forms highly uniform (monodisperse), stable, and small micelles (5-12 nm), leading to better tissue penetration and drug delivery efficiency.
• Low critical micelle concentration (cmc) compared to traditional surfactants and PEG-based systems, meaning they function effectively at low doses.
• Produced through modular and efficient 'click' chemistry, allowing for fast, reliable synthesis of well-defined structures.
• Excellent biocompatibility and water solubility, reducing risk of toxicity and adverse reactions in vivo.
• Nonionic nature leads to better tolerance and less immune response than ionic surfactants.
• Capable of both passive and active drug targeting due to suitable aggregate size and structure, potentially exploiting enhanced permeability and retention (EPR) effect in tumors.
• Versatile chemical structure allows for tuning of properties (e.g., using aromatic or fluorinated groups) to optimize loading capacity, stability, and targeting.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to novel linear-dendritic polyglycerol compounds, to a method for the production thereof and the use thereof for solubilizing hydrophobic substances, in particular as carrier or transport system for active substances and/or signal substances.