Method for Manufacturing a Hyperbranched Polyester Polyol Derivative

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention describes a straightforward two-step method to create sulfated hyperbranched polyester polyol derivatives. It involves polymerizing glycidol and ε-caprolactone to form a hyperbranched polyester polyol with randomly distributed hydrophobic and hydrophilic regions, followed by a sulfation step. The resulting material is biodegradable, biocompatible, and possesses anti-inflammatory activity, making it suitable as both a therapeutic agent and a drug delivery carrier, especially for targeting and treating inflammatory conditions.

Use CasesContent extracted from patent full text and abstract with AI.

• Active pharmaceutical ingredient with anti-inflammatory properties for treating inflammatory diseases.
• Carrier for delivering therapeutics, particularly hydrophobic drugs, through the skin or to specific tissues (e.g., inflammatory sites).
• Intradermal drug delivery systems to transport drugs efficiently into and through the skin.
• Diagnostic agent by conjugating probes (such as fluorescent or magnetic labels) for targeted imaging of inflammatory tissues.
• Targeted therapy where the polymer acts as both the therapeutic and the drug delivery platform, e.g., for conditions involving immune system activation or inflammation.

BenefitsContent extracted from patent full text and abstract with AI.

• Simple, scalable, and efficient synthesis without the need for complex copolymerization or toxic reagents.
• Biodegradable and biocompatible, minimizing toxicity and accumulation in tissues.
• Amphiphilic structure allows for high loading efficiency and transport of hydrophobic therapeutic agents.
• Demonstrated ability to penetrate the skin and enhance drug delivery while minimizing adverse effects on healthy tissue.
• Intrinsically anti-inflammatory, inhibiting complement activation and L-selectin-mediated recruitment, which are important in many inflammatory diseases.
• Versatile platform: can serve as both an active drug and a carrier for additional therapeutic or diagnostic molecules.
• Stable under neutral and acidic conditions, but susceptible to enzymatic cleavage, facilitating controlled biodegradation and drug release.

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Inventors & Applicants

Patent Abstract

The present invention relates to a method for manufacturing a hyperbranched polyester polyol derivative, comprising the following steps: a) reacting only glycidol and µ-caprolactone to obtain a hyperbranched polyester polyol in which caprolactone residues are randomly arranged; b) reacting the hyperbranched polyester polyol of step a) with a sulfation reagent to obtain a sulfated hyperbranched polyester polyol as hyperbranched polyester polyol derivative. Aspects of the invention relate to a hyperbranched polyester polyol derivative obtainable by this method as well as uses thereof.