Polymer for Inhibiting Sars-Cov-2 and Other Pathogens

Simple SummaryContent extracted from patent full text and abstract with AI.

The invention describes a new class of methacrylate-based, dendronized polyglycerol polymers that are highly functionalized and biocompatible. These polymers are designed to inhibit SARS-CoV-2 and other respiratory viruses (such as herpes simplex virus HSV-1 and respiratory syncytial virus RSV) and certain pathogenic bacteria. The polymers can form degradable hydrogels, making them suitable for pharmaceutical applications (e.g., nasal sprays, mucus replacement). They exhibit high effectiveness in binding and neutralizing targeted viruses, provide low anticoagulant risk, and can be synthesized in large quantities at scale.

Use CasesContent extracted from patent full text and abstract with AI.

• Active ingredient in nasal sprays or inhalable formulations to block or inactivate SARS-CoV-2 and other respiratory viruses.
• Topical antiviral or antibacterial therapies (such as gels or creams) for treating or preventing infections.
• Mucus, cartilage, or synovial fluid replacement materials with built-in antiviral and antibacterial properties.
• Cell culture matrices or scaffolds for the cultivation and expansion of cells and organoids in research or regenerative medicine.
• Coatings for medical devices to reduce viral and bacterial infection risks.
• Wound dressings with antimicrobial and antiviral functionality.

BenefitsContent extracted from patent full text and abstract with AI.

• Highly effective inhibition of SARS-CoV-2, HSV-1, RSV, influenza, and various bacteria (including E. coli and Pseudomonas).
• Low anticoagulant activity, reducing risk of bleeding and making them safer for clinical use compared to standard sulfated polymers like heparin.
• High biocompatibility and low cytotoxicity, suitable for pharmaceutical and medical applications.
• Broad-spectrum antiviral and antibacterial effects in a single material.
• Ability to form degradable hydrogels with tunable viscoelastic properties, useful for diverse biomedical applications such as tissue engineering and drug delivery.
• Scalable and straightforward synthesis pathways, enabling production in bulk quantities.

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Inventors & Applicants

Patent Abstract

The present invention relates to methacrylate-based functionalized dendronized polyglycerol polymers. These polymers are highly biocompatible and less anticoagulant, form thread-like single chain fibers and show excellent inhibition against respiratory viruses such as SARS-CoV-2 and HSV-1. They can be easily used for forming degradable hydrogels together with a crosslinker.