Method for Identifying a Metabolite That Is Suited to Be Used in Diagnostics of a Liver Disease or of a Severity of a Liver Disease

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This invention describes a method to identify specific metabolites in a person's breath that can be used as biomarkers for diagnosing liver diseases or determining how severe a liver disease is. It involves measuring the concentration of certain volatile organic compounds (VOCs) in exhaled air and comparing them among healthy people (with different diets) and people with liver disease. Using a quantitative liver function test (like the LiMAx test), the method ensures that identified biomarkers are truly specific for liver dysfunction and not influenced by diet or other factors. The method has identified several metabolites that are particularly suitable as diagnostic markers for liver disease.

Use CasesContent extracted from patent full text and abstract with AI.

• Non-invasive diagnosis of liver diseases using breath analysis.
• Monitoring progression or severity of liver diseases in patients.
• Screening at-risk populations for early liver dysfunction.
• Personalized treatment planning based on liver function status.
• Point-of-care or home-based monitoring for patients with chronic liver conditions.
• Research on metabolic signatures associated with liver diseases.

BenefitsContent extracted from patent full text and abstract with AI.

• Provides a non-invasive and patient-friendly diagnostic method (breath test).
• Enables early and reliable detection of liver diseases and quantification of disease severity.
• Differentiates between true liver impairment and other influences (like diet), minimizing false results.
• Allows for continuous or repeatable monitoring over time, aiding in disease management and treatment adjustment.
• Identifies specific metabolites as robust biomarkers for improved diagnostic accuracy.
• Can potentially reduce need for invasive procedures like liver biopsies.

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Patent Abstract

The invention relates to a novel method for identifying a metabolite that is suited to be used in diagnostics of a liver disease or of a severity of a liver disease. The following metabolites have been identified as suited biomarkers by this method: carbonyl sulfide, dimethylsilane, acetic acid, propanol, cysteine, S-methyl thioacrylate, bis-(methylthio)methane, 3-mercaptopropane-,2-diol, ethenamine, n-butylamine, serine, trimethylamine, ornithine, cinnamaldehyde, glutamine, diallyl disulfide, glutamic acid, selenocystein, hydrogen cyanide, methionine, 2- mercaptoindole, dimethyl sulfoxide, benzene, and 2-mercaptoethanol.