Silicon containing compounds and their use as anti-inflammatory agents

Simple SummaryContent extracted from patent full text and abstract with AI.

The invention describes a new class of silicon-containing compounds, specifically derivatives of 2-(4-(dimethylsilylmethyl)phenyl) propionic acid and related structures. These compounds act as anti-inflammatory, analgesic, and antipyretic agents, similar to ibuprofen but with improved pharmacological properties such as better absorption and longer retention in the body. The compounds and their pharmaceutical compositions can be used to prevent or treat inflammatory diseases, pain, and fever.

Use CasesContent extracted from patent full text and abstract with AI.

• Oral or injectable drugs for pain relief (analgesic)
• Treatment and prevention of inflammatory diseases such as arthritis, rheumatism, gout, Crohn's disease, and ulcerative colitis
• Reduction of fever (antipyretic applications)
• Pharmaceutical compositions such as tablets, gels, injections, capsules, suppositories, ointments, creams, or sprays for clinical use
• Therapy of headaches, migraines, and pain associated with inflammation

BenefitsContent extracted from patent full text and abstract with AI.

• Improved body absorption compared to traditional NSAIDs such as ibuprofen
• Longer elimination half-life leading to prolonged therapeutic effect and reduced dosing frequency
• Potentially lower daily dose needed to achieve therapeutic effects
• Multiple dosage forms possible, increasing flexibility for different patient needs and clinical situations
• Effective for a broad range of inflammatory diseases and pain conditions
• Potential for fewer side effects or improved safety profile due to improved pharmacokinetics

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to a silicon containing compound of general formula I or their (R)- or (S)-enantiomer or salts or esters thereof, wherein X represents hydrogen or deuterium R represents CH 3 , C 2 H 5 , CF 3 or C 2 F 5 and n is 1-3 and their use as anti-inflammatory agent.