Dendritic Polyglycerol Sulfates and Sulfonates and Their Use in Inflammatory Diseases

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent discloses novel chemical compounds known as dendritic polyglycerol sulfates and sulfonates, which have a highly branched, tree-like polymer structure. These compounds can be engineered to contain various amounts of sulfate or sulfonate groups, providing them with high affinity for selectin molecules involved in inflammation. The invention covers their synthesis, pharmaceutical compositions, and various uses, particularly as treatments or diagnostic tools for inflammatory diseases. They can act as potent inhibitors or indicators of selectins, reducing abnormal leukocyte migration, and can be loaded with signaling molecules for imaging inflammatory disorders.

Use CasesContent extracted from patent full text and abstract with AI.

• Therapeutic treatment of inflammatory diseases like rheumatoid arthritis, asthma, and psoriasis.
• Prevention and management of ischemia-reperfusion injury and transplant graft rejection.
• As selectin inhibitors to reduce harmful leukocyte adhesion and migration in inflammation.
• As labeled molecular probes for imaging and diagnosing inflammatory diseases using attached dyes or radioisotopes.
• As in vitro tools for purifying or detecting proteins such as selectins, chemokines, or coagulation factors in biological samples (e.g., ELISA, affinity matrices).
• Potential as 'heparin-like' analogues for specific cytokine modulation or anticoagulation-related studies.

BenefitsContent extracted from patent full text and abstract with AI.

• High specificity and strong inhibitory effect against L-selectin and P-selectin (important targets in inflammatory disease).
• Easy and cost-effective to synthesize with tunable molecular properties such as branching and degree of functionalization.
• Biocompatible and potentially low toxicity—similar to naturally occurring substances like heparin.
• Versatility: suitable for both therapeutic interventions and diagnostic imaging/targeting applications.
• Enhanced efficacy compared to conventional inhibitors (e.g., heparin), with much lower required concentrations.
• Potential for combining diagnostic and therapeutic functions in a single molecule (theranostics).

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to the novel compound classes of dendritic polyglycerol sulfates and sulfonates as well as to their production and use for the treatment of diseases, particularly inflammatory diseases, and to their use as selectin inhibitors and selectin indicators. The dendritic polyglycerol sulfates and sulfonates are also suitable for imaging diagnostics, particularly with respect to inflammatory diseases.