Metal salophen complexes use in prevention and treatment of cancer

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent discloses the use of metal salophen complexes, particularly those containing metals like iron, cobalt, nickel, copper, manganese, and zinc, for the prevention and treatment of cancer. The invention demonstrates that these complexes, especially iron-based ones, show strong cytotoxic and anti-proliferative effects on various types of cancer cells—often at lower concentrations and higher efficacy than established drugs such as cisplatin. Pharmaceutical compositions containing these complexes can be formulated for oral, injectable, or other delivery forms.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of breast cancer, colorectal cancer, lung, gastric, pancreatic, and esophagus cancers and their metastases.
• Prevention of cancer recurrence or metastasis post-surgery or initial therapy.
• Treatment of blood cancers, such as leukemia.
• Inclusion in combination chemotherapy protocols to enhance anticancer efficacy or overcome drug resistance.
• Development of oral, injectable, or nanoparticle-based (e.g., liposomal) cancer drug formulations.

BenefitsContent extracted from patent full text and abstract with AI.

• Metal salophen complexes exhibit stronger cytotoxic effects against cancer cells compared to standard chemotherapeutics (cisplatin, tamoxifen, 5-fluorouracil).
• Higher accumulation in cancer cells compared to established drugs increases local effectiveness and reduces systemic toxicity.
• Potentially effective against a broad range of cancers, including solid and hematologic tumors.
• Versatile formulation options (oral, injectable, nanoparticle) for flexible therapy.
• Possible reduction in side effects due to lower required doses for therapeutic effect.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to metal salophen complexes of general formulas I and/or II wherein Me(II) represents Fe, Co, Ni, Cu, Mn, Zn Me(III) represents Fe, Mn, AI, Cr R 1 to R 8 independently from each other represent hydrogen, halogen, hydroxy, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, trihalomethyl R 9 represents halogen or acetat or their salts or esters for use in prevention and treatment of cancer and to pharmaceutical compositions comprising these metal salophen complexes, especially iron salophen complexes.