Method for Producing Coated Glass Surfaces and Glass Containers Made Therewith

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This invention provides a method for coating glass surfaces, especially those used in storing or handling biomolecules and biological materials (such as pharmaceutical proteins, enzymes, or cells). The coating process involves activating the glass and applying a silyl-modified polyglycerol, which forms a robust, covalently bound anti-adhesive layer on the glass. This coated surface significantly reduces non-specific adsorption of biomolecules and remains stable under high-temperature sterilization, making it ideal for medical and biotechnological uses.

Use CasesContent extracted from patent full text and abstract with AI.

• Glass vials and containers for biopharmaceutical storage to prevent protein or biomolecule loss by adsorption.
• Labware and equipment (like pipettes, slides, microchannels) used in handling biological samples for clinical diagnostics or research.
• Microfluidic devices for manipulation and analysis of tiny biological or chemical samples.
• Glass reaction vessels for pharmaceutical manufacturing processes.
• Diagnostic assay surfaces to improve accuracy by reducing non-specific binding.

BenefitsContent extracted from patent full text and abstract with AI.

• Minimizes non-specific protein and biomolecule adsorption, leading to higher recovery and integrity of stored/handled substances.
• Provides a surface coating that is resistant to thermal sterilization and autoclaving, enabling safe and repeated use in sterile environments.
• Extends the shelf-life and activity of sensitive biological substances by preventing denaturation.
• Enables straightforward manufacturing without the need for inert gas or strictly water-free conditions, reducing complexity and cost.
• Applicable to a wide range of glassware and devices in medicine, pharmaceuticals, biotechnology, and analytical diagnostics.
• Reduces contamination risk from bacterial adhesion, thanks to improved anti-adhesive properties.

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Patent Abstract

The invention relates to a method for coating glass surfaces, particularly surfaces of glass containers, for biomolecules and biological materials, the method being characterized in that the glass surface is activated and a silyl-modified polyglycerol is applied to said activated glass surface, the silyl-modified polyglycerol being structured in such a manner that the silyl linker is coupled to the polyglycerol via a urea bond, and a covalently bonded layer is formed on the glass surface via the silyl linker. The silyl linker is selected from trialkoxysilyl, dialkoxyalkylsilyl or monoalkoxydialkylsilyl. The glass surface coated in this manner is stable under thermal sterilization conditions.