Photocurable Composition

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This patent describes a novel photocurable composition ("resin") specifically designed for 3D printing, particularly stereolithography (SLA). The composition uses functionalized gelatin and/or decellularized extracellular matrix (dECM) as photocrosslinkable prepolymers, formamide as a unique solvent to ensure proper dissolution and optimal printability, and a photoinitiator for polymer crosslinking when exposed to light. The addition of functionalized poly(ε-caprolactone) (PCL) improves print resolution and mechanical properties. This composition enables the 3D fabrication of high-resolution, cell-friendly scaffolds that mimic natural tissue environments, supporting cell growth and tissue engineering applications.

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• Fabrication of custom tissue engineering scaffolds for regenerative medicine.
• Creation of organ-mimicking in vitro models for drug screening and disease studies.
• Manufacturing of biocompatible implants tailored to patient-specific anatomies.
• Production of permeable, cell-adhesive materials for lab-on-chip devices or organ-on-chip platforms.
• Development of advanced cell culture substrates that better replicate physiological conditions.

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• Enables high-resolution 3D printing of hydrated, biocompatible scaffolds suitable for cell adhesion and growth.
• Provides improved control over scaffold permeability and mechanical properties through customizable resin composition.
• Supports the fabrication of complex, biomimetic structures that closely mimic native tissue microarchitecture.
• Minimizes issues of solvent evaporation and inconsistent polymer concentration during printing, ensuring reproducibility and accuracy.
• Expands the range of materials (e.g., dECM, functionalized biopolymers) compatible with SLA-based 3D printing, opening new avenues in biofabrication.

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Inventors & Applicants

Patent Abstract

The present invention relates to a photocurable composition for 3D printing, comprising a) at least one photocurable prepolymer chosen from the group consisting of functionalized gelatin bearing a first functional group and functionalized decellularized extracellular matrix bearing a second functional group; b) at least one solvent, the solvent being formamide; and c) at least one photoinitiator.