Linker Molecule and Use Thereof in Methods for Purifying Peptides

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This invention discloses novel linker molecules and a method for purifying peptides produced by solid phase peptide synthesis (SPPS). The key concept is to use specialized linker molecules to attach the target peptide to a solid support, allowing contaminants to be washed away. The desired peptide can then be selectively released from the support under specific conditions, improving the efficiency and scalability of peptide purification. The process avoids common issues associated with conventional methods such as HPLC, including poor scalability, high costs, and limitations with certain peptide types.

Use CasesContent extracted from patent full text and abstract with AI.

• Purification of synthetic peptides in pharmaceutical manufacturing, especially therapeutic peptides.
• Research laboratories synthesizing custom peptides for biological experiments.
• Large-scale industrial peptide production, where high purity and cost-effective processing are essential.
• Purification of peptides prone to complexing metal ions (like those containing cysteine or methionine) that are otherwise difficult to purify using conventional HPLC methods.
• Production of peptides for diagnostic or analytical applications.

BenefitsContent extracted from patent full text and abstract with AI.

• Enables high-purity peptide isolation without the need for expensive and less scalable HPLC equipment.
• The method is compatible with a wide range of peptides, including those containing thiols or metal-chelating residues.
• Reusable solid phase support (e.g., modified agarose or cellulose), making it cost-effective and environmentally friendly.
• The process is simple, scalable, and suitable for both small-scale research and large-scale industrial peptide synthesis.
• Reduces consumption of organic solvents and specialized chromatographic columns, lowering operational costs.
• Allows selective and mild release of purified peptides, preserving their integrity and activity.

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Patent Abstract

The invention relates to a method for purifying peptides which are produced by solid phase peptide synthesis (SPPS) and corresponding linker molecules for use in said method.