Synthesis and Use of Novel Drimane Sesquiterpenoids of Khamkhaine Type from Thai Basidiomycota

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention provides a synthetic method to produce novel drimane sesquiterpenoid compounds, specifically of the khamkhaine type, which are derived from Thai Basidiomycota. The invention not only outlines the chemical synthesis pathway for these compounds and their stereoisomeric forms, but also claims their use as pharmaceutical agents, particularly for treating neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and ALS. The compounds have shown promising neurotrophic activity, including the induction of neurotrophic factors and promotion of neurite outgrowth.

Use CasesContent extracted from patent full text and abstract with AI.

• Development of new pharmaceutical drugs for neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS.
• Research tool to further study mechanisms involved in neuroprotection and neuron repair.
• Template for synthesizing related bioactive sesquiterpenoid analogues for biological and pharmacological studies.
• Component in neuroprotective therapies, potentially in combination treatments.
• Use in formulation of oral, injectable, or inhalable medications targeting neurodegenerative disease progression.

BenefitsContent extracted from patent full text and abstract with AI.

• Enables access to novel, natural-product-like molecules with demonstrated neurotrophic activity.
• Synthetic accessibility allows production at scale and the creation of analogues for drug development.
• Potential to address unmet medical needs in neurodegenerative diseases, which affect millions globally.
• Can lead to new disease-modifying therapies rather than symptomatic treatments for neurodegenerative disorders.
• Flexibility in formulation and delivery routes (oral, injectable, etc.) increases clinical utility.
• Supports drug discovery by providing a new class of bioactive compounds with modifiable stereochemistry.

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Patent Abstract

The present invention refers to a method for the preparation of a compound according to formula (45), its enantiomers, diastereomers, a racemic mixture, and the pharmaceutically acceptable salts thereof. Furthermore the invention refers to a compound of formula (45) prepared by said method for use in treatment of neurodegenerative disorders and to pharmaceutical compositions.