Disorazoles and Their Analogues and Methods for Their Production

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent relates to new disorazoles and their analogues, a class of complex organic molecules with strong anti-cancer properties. It introduces both novel compounds and efficient synthetic methods for producing disorazoles and their analogues on a large scale, using only two main chemical precursors in a stepwise process that results in high yields and purity. Notably, the method allows fine stereochemical control, making it possible to generate desired isomers for pharmaceutical applications, such as cancer treatment.

Use CasesContent extracted from patent full text and abstract with AI.

• Development of anti-cancer drugs or chemotherapeutic agents.
• Pharmaceutical formulation for the treatment of various tumor types.
• Research tools for studying cytoskeletal inhibition and cell division in cancer biology.
• Potential use in combination therapy with other anticancer agents for improved efficacy.
• Production of disorazole analogues for screening and drug discovery in oncology.

BenefitsContent extracted from patent full text and abstract with AI.

• Efficient and scalable production method, enabling large-scale synthesis with high yield and purity.
• Simplified synthesis using only two main precursors, reducing complexity and cost.
• Ability to control and select stereochemistry, allowing the production of specific active isomers.
• Facilitates the discovery and development of new anti-cancer agents by broadening the chemical diversity of disorazole analogues.
• Supports pharmaceutical development with methods for producing pharmaceutically acceptable salts and preparations.
• Potential for generating a wide range of analogues for optimization of therapeutic properties and reduced side effects.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention describes disorazoles and their analogues as described in formula IIIwherein the variables are defined in the description, or pharmaceutically acceptable salts thereof.Described is also a novel synthetic pathway for the production of disorazoles and their analogues, using two precursors twice in coupling reactions and a final cyclisation for a compound of formula III.The compounds of the present invention are useful as anti-cancer drugs.