Method for detection of a disease-specific combinatorial molecular pattern motif in a tissue sample of a patient's skin

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes a method for detecting specific disease-related molecular patterns in skin or mucosal tissue samples using labeled antibodies or ligands. The method identifies unique spatial arrangements of epitopes—parts of proteins—related to diseases such as psoriasis and atopic dermatitis. By analyzing these patterns with advanced imaging and analysis technologies (notably MELC robot technology), the method allows for a more precise and rapid diagnosis of inflammatory skin diseases. The patent also covers compositions, diagnostic kits, and biochips that include antibodies or ligands for practical laboratory use.

Use CasesContent extracted from patent full text and abstract with AI.

• Laboratory diagnosis of psoriasis using skin biopsies.
• Laboratory diagnosis of atopic dermatitis using skin or mucosal biopsies.
• Development of diagnostic kits for skin clinics and dermatologists.
• Automated analysis of skin conditions in clinical research and trials.
• Personalized treatment planning based on molecular pattern identification.
• Development of biochips for multiplexed skin disease diagnostics.
• Support for pharmaceutical development and evaluation of therapies (e.g. efficacy of treatments targeting specific molecular motifs).
• Differentiating between similar skin conditions (e.g., distinguishing inflammatory dermatoses from lymphoma).

BenefitsContent extracted from patent full text and abstract with AI.

• Enables reliable, objective, and rapid diagnosis of psoriasis and atopic dermatitis.
• Reduces reliance on subjective visual examination and dermatologist experience, improving diagnostic accuracy.
• Identifies disease-specific molecular signatures at a high resolution.
• Supports the development of quick-turnaround diagnostic kits for lab and clinical use.
• Helps doctors select more effective and tailored therapies.
• Potentially shortens time to diagnosis and treatment, improving patient care.
• Facilitates advanced research into skin disease mechanisms by mapping combinatorial protein patterns.
• Reduces risk of misdiagnosis and inappropriate treatment.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to a method for detection of a disease-specific combinatorial molecular pattern motif in a tissue sample of a patient's skin and/or a tissue sample of skin-neighboured-mucosa, wherein the spatial arrangement of epitopes in the sample is captured for identifying the disease-specific combinatorial molecular pattern motif. The invention moreover relates to compositions and kits comprising antibodies and/or ligands which can be employed for the performance of the method.